Overview

  • Product name

    Anti-ANTXR2/CMG-2 antibody
    See all ANTXR2/CMG-2 primary antibodies
  • Description

    Goat polyclonal to ANTXR2/CMG-2
  • Host species

    Goat
  • Specificity

    This antibody is expected to recognize both reported isoforms (NP_477520.2; NP_001139266.1).
  • Tested applications

    Suitable for: Flow Cyt, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cow, Dog
  • Immunogen

    Synthetic peptide corresponding to Human ANTXR2/CMG-2 aa 121-133 (internal sequence) (Cysteine residue). (NP_001139266.1)
    Sequence:

    HEGLKLANEQIQK


    Database link: NP_477520.2

  • Positive control

    • IHC-P: Human Liver and Kidney tissue.
  • General notes

    Previously labelled as ANTXR2. 

Properties

Applications

Our Abpromise guarantee covers the use of ab101711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration. PubMed: 24742682

ab37373 - Goat polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

 

ab37373 - Goat polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Necessary for cellular interactions with laminin and the extracellular matrix.
  • Tissue specificity

    Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
  • Involvement in disease

    Defects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH) [MIM:236490]. This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures.
    Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF) [MIM:228600]. JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility.
  • Sequence similarities

    Belongs to the ATR family.
    Contains 1 VWFA domain.
  • Domain

    Binding to PA seems to be effected through the VWA domain.
  • Cellular localization

    Secreted; Cell membrane. Expressed at the cell surface and Endoplasmic reticulum membrane. Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 2310046B19Rik antibody
    • Anthrax toxin receptor 2 antibody
    • ANTR2_HUMAN antibody
    • Antxr2 antibody
    • AW561899 antibody
    • Capillary morphogenesis gene 2 protein antibody
    • Capillary morphogenesis protein 2 antibody
    • CMG 2 antibody
    • CMG-2 antibody
    • CMG2 antibody
    • FLJ31074 antibody
    • HFS antibody
    • ISH antibody
    • JHF antibody
    • MGC111533 antibody
    • MGC45856 antibody
    see all

Images

  • ab101711 (2.5 µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

  • ab101711 (2.5 µg/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

References

This product has been referenced in:

  • Arévalo MT  et al. Targeted Silencing of Anthrax Toxin Receptors Protects against Anthrax Toxins. J Biol Chem 289:15730-15738 (2014). Flow Cyt, Blocking ; Human . Read more (PubMed: 24742682) »
See 1 Publication for this product

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