Key features and details
- Rabbit polyclonal to AP-Q
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-AP-Q antibody
DescriptionRabbit polyclonal to AP-Q
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
- Human placenta tissue.
Previously labelled as Laeverin.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab185345 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionMetalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C.
Tissue specificitySpecifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells. Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level).
Sequence similaritiesBelongs to the peptidase M1 family.
- Information by UniProt
- Aminopeptidase Q antibody
- AMPQ_HUMAN antibody
- AP-Q antibody
ab185345 has been referenced in 1 publication.
- Nystad M et al. Laeverin protein expression in normal and preeclamptic placentas using tissue microarray analysis. Acta Obstet Gynecol Scand 97:536-544 (2018). PubMed: 29355889