Overview

  • Product name

  • Description

    Rabbit polyclonal to AP1M2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    Recombinant fragment corresponding to Human AP1M2 aa 34-60.
    Sequence:

    MPLLVQREEEGALAPLLSHGQVHFLWI


    Database link: Q9Y6Q5

  • Positive control

    • Caco2 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab220678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Use PFA/Triton X-100 Fixation/Permeabilization.

Target

  • Function

    Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
  • Sequence similarities

    Belongs to the adaptor complexes medium subunit family.
    Contains 1 MHD (mu homology) domain.
  • Post-translational
    modifications

    Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.
  • Cellular localization

    Golgi apparatus. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
  • Information by UniProt
  • Database links

  • Alternative names

    • Adaptor protein complex AP-1 mu-2 subunit antibody
    • Adaptor protein complex AP1 mu2 subunit antibody
    • Adaptor related protein complex 1 mu2 subunit antibody
    • Adaptor-related protein complex 1 mu-2 subunit antibody
    • AP mu chain family member mu1B antibody
    • AP-1 complex subunit mu-2 antibody
    • AP-mu chain family member mu1B antibody
    • AP1 complex subunit mu2 antibody
    • AP1M2 antibody
    • AP1M2_HUMAN antibody
    • AP47 2 antibody
    • Clathrin assembly protein complex 1 medium chain 2 antibody
    • Golgi adaptor HA1/AP1 adaptin mu-2 subunit antibody
    • Golgi adaptor HA1/AP1 adaptin mu2 subunit antibody
    • HA1 47 kDa subunit 2 antibody
    • HSMU1B antibody
    • MU 1B antibody
    • Mu adaptin 2 antibody
    • Mu-adaptin 2 antibody
    • Mu1B adaptin antibody
    • Mu1B-adaptin antibody
    see all

Images

  • Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized Caco2 cells labeling AP1M2 with ab220678 at 4 µg/ml (green).

References

ab220678 has not yet been referenced specifically in any publications.

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