Anti-AP1S2 antibody (ab97590)
Key features and details
- Rabbit polyclonal to AP1S2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-AP1S2 antibody
See all AP1S2 primary antibodies -
Description
Rabbit polyclonal to AP1S2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Cow, Zebrafish -
Immunogen
Recombinant fragment containing a sequence corresponding to a region within amino acids 1-122 of Human AP1S2 (NP_003907).
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Positive control
- Raji whole cell lysate; A431 cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab97590 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 19 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 19 kDa. |
Target
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Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. -
Tissue specificity
Widely expressed. -
Involvement in disease
Defects in AP1S2 are the cause of mental retardation X-linked type 59 (MRX59) [MIM:300630]. It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. MRX59 consists of a mild-to-profound mental retardation. Other features includes hypotonia early in life and delay in walking. -
Sequence similarities
Belongs to the adaptor complexes small subunit family. -
Cellular localization
Golgi apparatus. Cytoplasmic vesicle membrane. Membrane > clathrin-coated pit. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. - Information by UniProt
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Database links
- Entrez Gene: 8905 Human
- Entrez Gene: 108012 Mouse
- Entrez Gene: 327237 Zebrafish
- Omim: 300629 Human
- SwissProt: P56377 Human
- SwissProt: Q9DB50 Mouse
- Unigene: 653504 Human
- Unigene: 720688 Human
see all -
Alternative names
- Adapter related protein complex 1 sigma 1B subunit antibody
- Adapter-related protein complex 1 sigma-1B subunit antibody
- Adaptor protein complex AP 1 sigma 1B subunit antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab97590 has been referenced in 1 publication.
- Field MJ et al. Different types of disease-causing noncoding variants revealed by genomic and gene expression analyses in families with X-linked intellectual disability. Hum Mutat 42:835-847 (2021). PubMed: 33847015