Overview

  • Product name

  • Description

    Rabbit polyclonal to AP1S2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Cow, Zebrafish
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 1-122 of Human AP1S2 (NP_003907).

  • Positive control

    • Raji whole cell lysate; A431 cell lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab97590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 19 kDa.

Target

  • Function

    Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
  • Tissue specificity

    Widely expressed.
  • Involvement in disease

    Defects in AP1S2 are the cause of mental retardation X-linked type 59 (MRX59) [MIM:300630]. It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. MRX59 consists of a mild-to-profound mental retardation. Other features includes hypotonia early in life and delay in walking.
  • Sequence similarities

    Belongs to the adaptor complexes small subunit family.
  • Cellular localization

    Golgi apparatus. Cytoplasmic vesicle membrane. Membrane > clathrin-coated pit. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
  • Information by UniProt
  • Database links

  • Alternative names

    • Adapter related protein complex 1 sigma 1B subunit antibody
    • Adapter-related protein complex 1 sigma-1B subunit antibody
    • Adaptor protein complex AP 1 sigma 1B subunit antibody
    • Adaptor protein complex AP-1 sigma-1B subunit antibody
    • Adaptor related protein complex 1 sigma 2 subunit antibody
    • AP 1 complex subunit sigma 2 antibody
    • AP-1 complex subunit sigma-2 antibody
    • ap1s2 antibody
    • AP1S2_HUMAN antibody
    • Clathrin adaptor complex AP1 sigma 1B subunit antibody
    • Clathrin assembly protein complex 1 sigma 1B small chain antibody
    • Clathrin assembly protein complex 1 sigma-1B small chain antibody
    • Clathrin associated assembly adaptor protein small 1 like antibody
    • DC22 antibody
    • Golgi adaptor HA1 AP1 adaptin sigma 1B subunit antibody
    • Golgi adaptor HA1/AP1 adaptin sigma-1B subunit antibody
    • mental retardation X linked 59 antibody
    • MGC:1902 antibody
    • MRX59 antibody
    • Sigma 1B subunit of AP 1 clathrin antibody
    • Sigma 1B subunit of AP-1 clathrin antibody
    • Sigma adaptin 1B antibody
    • Sigma-adaptin 1B antibody
    • Sigma1B adaptin antibody
    • SIGMA1B antibody
    • Sigma1B-adaptin antibody
    see all

Images

  • Anti-AP1S2 antibody (ab97590) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size: 19 kDa



    12% SDS-PAGE

References

ab97590 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab97590.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up