Product nameAPAF1 peptide
See all APAF1 proteins and peptides
Our Abpromise guarantee covers the use of ab7873 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesThis peptide is non-HPLC, or immunograde, and the purity is estimated to be 60-70%.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
- APAF 1
FunctionOligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Tissue specificityUbiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Sequence similaritiesContains 1 CARD domain.
Contains 1 NB-ARC domain.
Contains 13 WD repeats.
DomainThe CARD domain mediates interaction with APIP.
- Information by UniProt
ab7873 has not yet been referenced specifically in any publications.