Apamin, blocker of small conductance Ca2+-activated K+ channels (ab120268)

Overview

  • Product name

    Apamin, blocker of small conductance Ca2+-activated K+ channels
  • Description

    Blocker of small conductance Ca2+-activated K+ channels
  • Biological description

    Peptide neurotoxin that naturally occurs in Apis mellifera bee venom. Blocks small conductance Ca2+ activated K+ channels (SK). Selective for KCa2.1-2.3 (SK1-3) isoforms. Blocks hSK1, rSK2 and liver rSK3 (IC50 values are 8 nM, 83 pM and 0.6 nM, respectively).
  • Purity

    > 95%
  • CAS Number

    24345-16-2
  • Chemical structure

    Chemical Structure

Properties

Images

  • Confocal images from a transcardially-fixed rat brain previously injected with blockers (left-side dorsal striatum, Left DMS) and blockers plus apamin (right-side dorsal striatum, Right DMS) showing double staining for ChAT and p-Ser240–244-S6rp. Top panels are low-magnification images showing several cholinergic interneurons in the same focal plane. Bottom panels are higher magnification images showing p-S6rp signal intensity in CINs from the left (blockers) and right (blockers + apamin) striata of the same animal. Insets show corresponding ChAT staining.

    Bertran-Gonzalez J et al., PloS one., 7(12): e53195. Fig 6B.; doi: 10.1371/journal.pone.0053195

References

This product has been referenced in:

  • Barfod ET  et al. Cloning and functional expression of a liver isoform of the small conductance Ca2+-activated K+ channel SK3. Am J Physiol Cell Physiol 280:C836-42 (2001). Read more (PubMed: 11245600) »
  • Shah M & Haylett DG The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol 129:627-30 (2000). Read more (PubMed: 10683185) »
  • Strøbaek D  et al. Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol 129:991-9 (2000). Read more (PubMed: 10696100) »
See all 7 Publications for this product

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