APC Anti-CD24 antibody [M1/69] (ab218741)

Submit a review Submit a question
Flow Cytometry - APC Anti-CD24 antibody [M1/69] (ab218741)

    Key features and details

    • APC Rat monoclonal [M1/69] to CD24
    • Suitable for: Flow Cyt
    • Reacts with: Mouse
    • Conjugation: APC. Ex: 645nm, Em: 660nm
    • Isotype: IgG2b

    Overview

    • Product name

      APC Anti-CD24 antibody [M1/69]
      See all CD24 primary antibodies

    • Description

      APC Rat monoclonal [M1/69] to CD24

    • Host species

      Rat

    • Conjugation

      APC. Ex: 645nm, Em: 660nm

    • Tested applications

      Suitable for: Flow Cytmore details

    • Species reactivity

      Reacts with: Mouse

    • Immunogen

      The details of the immunogen for this antibody are not available.

    • Positive control

      • C57Bl/6 splenocytes.

    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    Applications

    Our Abpromise guarantee covers the use of ab218741 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Flow Cyt Use at an assay dependent concentration.

    Use 0.06 μg per test.

    Target

    • Function

      Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

    • Tissue specificity

      B-cells. Expressed in a number of B-cell lines including P32/SH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.

    • Involvement in disease

      Genetic variations in CD24 are associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Polymorphisms in CD24 may act as a genetic modifier for susceptibility and progression of MS in some populations, perhaps by affecting the efficiency of CD24 expression on the cell surface.

    • Sequence similarities

      Belongs to the CD24 family.

    • Post-translational
      modifications

      Extensively O-glycosylated.

    • Cellular localization

      Cell membrane.
    • Information by UniProt

    • Database links

      • Alternative names

        • CD 24 antibody
        • CD24 antibody
        • CD24 antigen (small cell lung carcinoma cluster 4 antigen) antibody
        • CD24 antigen antibody
        • CD24 molecule antibody
        • CD24_HUMAN antibody
        • CD24A antibody
        • FLJ22950 antibody
        • FLJ43543 antibody
        • GPI linked surface mucin antibody
        • Heat stable antigen antibody
        • HSA antibody
        • MGC75043 antibody
        • Nectadrin antibody
        • Signal transducer CD24 antibody
        • Small cell lung carcinoma cluster 4 antigen antibody
        see all

      Images

      • Flow Cytometry - APC Anti-CD24 antibody [M1/69] (ab218741)
        Flow Cytometry - APC Anti-CD24 antibody [M1/69] (ab218741)

        C57Bl/6 splenocytes were stained with 0.06 ug ab218741 (solid line) or 0.06 ug Allophycocyanin Rat IgG2b isotype control (dashed line).

      References (0)

      Publishing research using ab218741? Please let us know so that we can cite the reference in this datasheet.

      ab218741 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

      Show All Reviews Q&A
      Submit a review Submit a question

      There are currently no Customer reviews or Questions for ab218741.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com