Key features and details
- APC Mouse monoclonal [WM53] to CD33
- Reacts with: Human
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG1
Related conjugates and formulations
Product nameAPC Anti-CD33 antibody [WM53]
See all CD33 primary antibodies
DescriptionAPC Mouse monoclonal [WM53] to CD33
ConjugationAPC. Ex: 645nm, Em: 660nm
Species reactivityReacts with: Human
Tissue, cells or virus corresponding to CD33. Human AML cells
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.4
Preservative: 0.09% Sodium azide
Constituents: PBS, 0.2% BSA
Concentration information loading...
Purification notesThe purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- PerCP Anti-CD33 antibody [WM53] (ab124531)
- APC/Cy7® Anti-CD33 antibody [WM53] (ab206634)
- Anti-CD33 antibody [WM53] - BSA and Azide free (ab213050)
- PE/Cy5® Anti-CD33 antibody [WM53] (ab233448)
- PE Anti-CD33 antibody [WM53] (ab233577)
- FITC Anti-CD33 antibody [WM53] (ab234216)
- PE/Cy7® Anti-CD33 antibody [WM53] (ab239310)
- Anti-CD33 antibody [WM53] - BSA and Azide free (ab252263)
- Alexa Fluor® 700 Anti-CD33 antibody [WM53] (ab269306)
- Anti-CD33 antibody [WM53] (ab30371)
FunctionPutative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Tissue specificityMonocytic/myeloid lineage cells.
Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
DomainContains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
modificationsPhosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
Cellular localizationCell membrane.
- Information by UniProt
- CD 33 antibody
- CD33 antibody
- CD33 antigen (gp67) antibody
ab118967 has not yet been referenced specifically in any publications.