Key features and details
- APC Armenian hamster monoclonal [HMa2] to CD49b
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG
Product nameAPC Anti-CD49b antibody [HMa2]
See all CD49b primary antibodies
DescriptionAPC Armenian hamster monoclonal [HMa2] to CD49b
Host speciesArmenian hamster
ConjugationAPC. Ex: 645nm, Em: 660nm
Tested applicationsSuitable for: Flow Cytmore details
Species reactivityReacts with: Mouse
The details of the immunogen for this antibody are not available.
- Flow Cyt: C57BI/6 splenocytes.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C. Store In the Dark.
Storage bufferpH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.16% Sodium phosphate, 0.87% Sodium chloride, 0.1% Gelatin
Concentration information loading...
Purification notesPurified from Tissue culture supernatant.
Our Abpromise guarantee covers the use of ab253088 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Use at an assay dependent concentration.
Use at 0.125 µg per reaction.
RelevanceHuman CD49b is an integrin alpha 2 subunit that forms a heterodimer with beta 1 integrin and functions as an adhesion molecule. CD49b is a 160 kDa glycoprotein that noncovalently associates with the 130 kDa integrin beta 1 subunit (CD29) to form glycoprotein Ia/IIa (when expressed on platelets), and very late (activation) antigen 2 ('VLA2') when found on T cells. CD49b is expressed by platelets, approximately 50% of monocytes, long term cultivated T cells and most adherent cell lines. Integrin alpha 2/beta 1 is a receptor for laminin, collagen, collagen C propeptides, fibronectin and E cadherin. It recognizes the proline hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Cellular localizationCell Membrane; Single pass type I membrane protein.
- BR antibody
- CD49 antigen like family member B antibody
- CD49B antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab253088 has not yet been referenced specifically in any publications.