Key features and details
- APC Rat monoclonal [3C7] to IL-2 Receptor alpha
- Reacts with: Mouse
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG2b
Product nameAPC Anti-IL-2 Receptor alpha antibody [3C7]
See all IL-2 Receptor alpha primary antibodies
DescriptionAPC Rat monoclonal [3C7] to IL-2 Receptor alpha
ConjugationAPC. Ex: 645nm, Em: 660nm
Specificityab25485 recognises low affinity alpha chain IL-2 receptor (MW 55 kDa) (IL-2R alpha).
Species reactivityReacts with: Mouse
Tissue, cells or virus corresponding to IL-2 Receptor alpha. IL-2 dependent BALB/c helper T cell clone HT2
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.3
Preservative: 0.09% Sodium azide
Constituents: PBS, 16% Sucrose
Concentration information loading...
Light chain typekappa
ab25485 is useful for in vitro blocking of IL2 binding.
Flow Cyt: Use 0.3µg for 106 cells.
IP: Use at an assay dependent dilution.
Inhib: Use at an assay dependent dilution.
ab25485 inhibits IL2 or mitogen induced T cell proliferation.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionReceptor for interleukin-2.
Involvement in diseaseGenetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Sequence similaritiesContains 2 Sushi (CCP/SCR) domains.
- Information by UniProt
- Interleukin 2 receptor alpha chain antibody
- CD25 antibody
- CD25 antigen antibody
ab25485 has been referenced in 1 publication.
- Bursen A et al. The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4. Blood 115:3570-9 (2010). Flow Cyt ; Mouse . PubMed: 20194896