Key features and details
- APC Rat monoclonal [3C7] to IL-2 Receptor alpha
- Reacts with: Mouse
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG2b
Product nameAPC Anti-IL-2 Receptor alpha antibody [3C7]
See all IL-2 Receptor alpha primary antibodies
DescriptionAPC Rat monoclonal [3C7] to IL-2 Receptor alpha
ConjugationAPC. Ex: 645nm, Em: 660nm
Specificityab25485 recognises low affinity alpha chain IL-2 receptor (MW 55 kDa) (IL-2R alpha).
Species reactivityReacts with: Mouse
The details of the immunogen for this antibody are not available.
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.3
Preservative: 0.09% Sodium azide
Constituents: PBS, 16% Sucrose
Concentration information loading...
Light chain typekappa
ab25485 is useful for in vitro blocking of IL2 binding.
Flow Cyt: Use 0.3µg for 106 cells.
IP: Use at an assay dependent dilution.
Inhib: Use at an assay dependent dilution.
ab25485 inhibits IL2 or mitogen induced T cell proliferation.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionReceptor for interleukin-2.
Involvement in diseaseGenetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Sequence similaritiesContains 2 Sushi (CCP/SCR) domains.
- Information by UniProt
- Interleukin 2 receptor alpha chain antibody
- CD25 antibody
- CD25 antigen antibody
ab25485 has been referenced in 1 publication.
- Bursen A et al. The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4. Blood 115:3570-9 (2010). Flow Cyt ; Mouse . PubMed: 20194896