Key features and details
- APC Mouse monoclonal [359-81-11] to LTA
- Reacts with: Human
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG1
Product nameAPC Anti-LTA antibody [359-81-11]
See all LTA primary antibodies
DescriptionAPC Mouse monoclonal [359-81-11] to LTA
ConjugationAPC. Ex: 645nm, Em: 660nm
Species reactivityReacts with: Human
Recombinant full length protein corresponding to Human LTA.
- TH1 polarized restimulated PBMC's
This product was previously labelled as TNF beta
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.87% Sodium chloride, PBS
Concentration information loading...
PurityProtein G purified
FunctionCytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Involvement in diseaseGenetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
Sequence similaritiesBelongs to the tumor necrosis factor family.
Cellular localizationSecreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.
- Information by UniProt
- LTalpha antibody
- DAMA-25N12.13-004 antibody
- DIF antibody
ab95625 has been referenced in 3 publications.
- Yokley BH et al. A stimulation-dependent alternate core promoter links lymphotoxin a expression with TGF-ß1 and fibroblast growth factor-7 signaling in primary human T cells. J Immunol 190:4573-84 (2013). Human . PubMed: 23547113
- Duddy ME et al. Distinct profiles of human B cell effector cytokines: a role in immune regulation? J Immunol 172:3422-7 (2004). PubMed: 15004141
- Chun E et al. Tumor eradication by hepatitis B virus X antigen-specific CD8+ T cells in xenografted nude mice. J Immunol 170:1183-90 (2003). PubMed: 12538674