APC Anti-LTA antibody [359-81-11] (ab95625)
Key features and details
- APC Mouse monoclonal [359-81-11] to LTA
- Reacts with: Human
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG1
Overview
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Product name
APC Anti-LTA antibody [359-81-11]
See all LTA primary antibodies -
Description
APC Mouse monoclonal [359-81-11] to LTA -
Host species
Mouse -
Conjugation
APC. Ex: 645nm, Em: 660nm -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human LTA.
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Positive control
- TH1 polarized restimulated PBMC's
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General notes
This product was previously labelled as TNF beta
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
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We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.87% Sodium chloride, PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
359-81-11 -
Isotype
IgG1 -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Target
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Function
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. -
Involvement in disease
Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). -
Sequence similarities
Belongs to the tumor necrosis factor family. -
Cellular localization
Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated. - Information by UniProt
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Database links
- Entrez Gene: 4049 Human
- Omim: 153440 Human
- SwissProt: P01374 Human
- Unigene: 36 Human
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Alternative names
- LTalpha antibody
- DAMA-25N12.13-004 antibody
- DIF antibody
see all
Datasheets and documents
References (3)
ab95625 has been referenced in 3 publications.
- Yokley BH et al. A stimulation-dependent alternate core promoter links lymphotoxin a expression with TGF-ß1 and fibroblast growth factor-7 signaling in primary human T cells. J Immunol 190:4573-84 (2013). Human . PubMed: 23547113
- Duddy ME et al. Distinct profiles of human B cell effector cytokines: a role in immune regulation? J Immunol 172:3422-7 (2004). PubMed: 15004141
- Chun E et al. Tumor eradication by hepatitis B virus X antigen-specific CD8+ T cells in xenografted nude mice. J Immunol 170:1183-90 (2003). PubMed: 12538674
