APC Anti-sTRAIL Receptor 2 antibody [DR5-01-1] (ab243080)
![Flow Cytometry - APC Anti-sTRAIL Receptor 2 antibody [DR5-01-1] (ab243080)](https://www.abcam.com/ps/products/243/ab243080/Images/ab243080-332241-anti-strail-receptor-2-antibody-dr5-01-1-allophycocyanin-flow-cytometry.jpg "Flow Cytometry - APC Anti-sTRAIL Receptor 2 antibody [DR5-01-1] (ab243080)")
Key features and details
- APC Mouse monoclonal [DR5-01-1] to sTRAIL Receptor 2
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG1
Overview
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Product name
APC Anti-sTRAIL Receptor 2 antibody [DR5-01-1] -
Description
APC Mouse monoclonal [DR5-01-1] to sTRAIL Receptor 2 -
Host species
Mouse -
Conjugation
APC. Ex: 645nm, Em: 660nm -
Tested applications
Suitable for: Flow Cytmore details -
Species reactivity
Reacts with: Human -
Immunogen
Fusion protein corresponding to Human sTRAIL Receptor 2. Human IgG heavy chain and extracellular domain of sTRAIL Receptor 2 .
Database link: O14763 -
Positive control
- Flow Cyt: sTRAIL Receptor 2-transfectants.
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. Store In the Dark. -
Storage buffer
pH: 7.4
Preservative: 0.0975% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Size exclusion -
Purification notes
The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. -
Clonality
Monoclonal -
Clone number
DR5-01-1 -
Isotype
IgG1 -
Research areas
Associated products
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab243080 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt | Use a concentration of 2 µg/ml. |
Target
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Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. -
Tissue specificity
Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. -
Involvement in disease
Squamous cell carcinoma of the head and neck -
Sequence similarities
Contains 1 death domain.
Contains 3 TNFR-Cys repeats. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 8795 Human
- Omim: 603612 Human
- SwissProt: O14763 Human
- Unigene: 521456 Human
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Alternative names
- Apoptosis inducing protein TRICK2A 2B antibody
- Apoptosis inducing protein TRICK2A/2B antibody
- Apoptosis inducing receptor TRAIL R2 antibody
see all
Images
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Flow Cytometry - APC Anti-sTRAIL Receptor 2 antibody [DR5-01-1] (ab243080)
Flow Cytometry analysis of sTRAIL Receptor 2 transfectants labeling sTRAIL Receptor 2 with ab243080 at 2 μg/ml. Surface staining.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab243080 has not yet been referenced specifically in any publications.
