Anti-Apc10 antibody (ab126204)
Key features and details
- Rabbit polyclonal to Apc10
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Apc10 antibody
See all Apc10 primary antibodies -
Description
Rabbit polyclonal to Apc10 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Chicken, Cow, Xenopus laevis -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 1-135 of Human Apc10 (Q9UM13).
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Positive control
- MCF7 whole cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab126204 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 21 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 21 kDa. |
Target
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Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. -
Pathway
Protein modification; protein ubiquitination. -
Sequence similarities
Belongs to the APC10 family.
Contains 1 DOC domain. - Information by UniProt
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Database links
- Entrez Gene: 783986 Cow
- Entrez Gene: 10393 Human
- Entrez Gene: 68999 Mouse
- Entrez Gene: 361389 Rat
- Entrez Gene: 734319 Xenopus laevis
- Omim: 613745 Human
- SwissProt: Q2YDH1 Cow
- SwissProt: Q9UM13 Human
see all -
Form
It localises to Cytosol and nucleoplasm. -
Alternative names
- ANAPC 10 antibody
- anapc10 antibody
- Anaphase promoting complex 10 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab126204 has been referenced in 1 publication.
- Sako K et al. Emi2 mediates meiotic MII arrest by competitively inhibiting the binding of Ube2S to the APC/C. Nat Commun 5:3667 (2014). PubMed: 24770399