Overview

  • Product name

  • Description

    Rabbit polyclonal to Apc11
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Xenopus laevis, Zebrafish, Xenopus tropicalis
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 26-84 of Human Apc11 (Uniprot ID: Q9NYG5).

  • Positive control

    • 293T, H1299, HeLaS3, HepG2, MOLT4, Raji whole cell lysate

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab154546 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 9 kDa.

Target

  • Function

    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
  • Tissue specificity

    Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Belongs to the RING-box family.
    Contains 1 RING-type zinc finger.
  • Domain

    The RING-type zinc finger domain coordinates an additional third zinc ion.
  • Post-translational
    modifications

    Auto-ubiquitinated.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • ANAPC 11 antibody
    • ANAPC11 antibody
    • Anaphase promoting complex subunit 11 (yeast APC11 homolog) antibody
    • Anaphase promoting complex subunit 11 antibody
    • Anaphase promoting complex subunit 11 homolog (yeast) antibody
    • Anaphase promoting complex subunit 11 homolog antibody
    • Anaphase-promoting complex subunit 11 antibody
    • Apc 11 antibody
    • Apc 11p antibody
    • APC11 anaphase promoting complex subunit 11 homolog (yeast) antibody
    • APC11 anaphase promoting complex subunit 11 homolog antibody
    • APC11 antibody
    • APC11_HUMAN antibody
    • Apc11p antibody
    • Cyclosome subunit 11 antibody
    • Hepatocellular carcinoma associated RING finger protein antibody
    • Hepatocellular carcinoma-associated RING finger protein antibody
    • HSPC 214 antibody
    • HSPC214 antibody
    • MGC882 antibody
    • Yeast APC 11 homolog antibody
    • Yeast APC11 homolog antibody
    see all

Images

  • All lanes : Anti-Apc11 antibody (ab154546) at 1/5000 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : MOLT4 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 9 kDa



    15% SDS PAGE

References

ab154546 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab154546.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up