Anti-Apc11 antibody (ab44708)
- Datasheet
- References (1)
- Protocols
Overview
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Product nameAnti-Apc11 antibody
See all Apc11 primary antibodies -
DescriptionRabbit polyclonal to Apc11
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Host speciesRabbit
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Tested applicationsSuitable for: WBmore details
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Species reactivityReacts with: Mouse, Human
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Immunogen
Full length protein corresponding to Human Apc11.
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Positive control
- HeLa, NIH-3T3 cells
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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Storage bufferpH: 7.40
Preservative: 0.1% Sodium azide
Constituent: 0.01% PBS -
Concentration information loading...
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PurityProtein G purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
Our Abpromise guarantee covers the use of ab44708 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | 1/400. Predicted molecular weight: 10 kDa. |
Target
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FunctionComponent of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
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Tissue specificityExpressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
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PathwayProtein modification; protein ubiquitination.
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Sequence similaritiesBelongs to the RING-box family.
Contains 1 RING-type zinc finger. -
DomainThe RING-type zinc finger domain coordinates an additional third zinc ion.
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Post-translational
modificationsAuto-ubiquitinated. -
Cellular localizationCytoplasm. Nucleus.
- Information by UniProt
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Database links
- Entrez Gene: 51529 Human
- Entrez Gene: 66156 Mouse
- Omim: 614534 Human
- SwissProt: Q9NYG5 Human
- SwissProt: Q9CPX9 Mouse
- Unigene: 534456 Human
- Unigene: 21645 Mouse
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Alternative names
- ANAPC 11 antibody
- ANAPC11 antibody
- Anaphase promoting complex subunit 11 (yeast APC11 homolog) antibody
see all
Protocols
References
This product has been referenced in:
- Lee SB et al. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Mol Cell 60:21-34 (2015). IP . Read more (PubMed: 26387737) »