Key features and details
- Mouse polyclonal to APCDD1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-APCDD1 antibody
DescriptionMouse polyclonal to APCDD1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Full length human APCDD1 protein (NP_694545.1).
- APCDD1 transfected 293T cell lysate.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Constituent: 2.68% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab73063 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 59 kDa.|
FunctionNegative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
Tissue specificityAbundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
Involvement in diseaseDefects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
Sequence similaritiesBelongs to the APCDD1 family.
Cellular localizationCell membrane.
- Information by UniProt
- Adenomatosis polyposis coli down regulated 1 antibody
- Adenomatosis polyposis coli down regulated 1 protein antibody
- Adenomatosis polyposis coli down-regulated 1 protein antibody
All lanes : Anti-APCDD1 antibody (ab73063) at 1 µg/ml
Lane 1 : APCDD1 transfected 293T cell lysate
Lane 2 : Non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size: 59 kDa
Observed band size: 70 kDa why is the actual band size different from the predicted?
ab73063 has been referenced in 1 publication.
- Cho SG APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway. Oncol Lett 14:4845-4852 (2017). PubMed: 29085490