Overview

  • Product name

  • Description

    Rabbit polyclonal to Aph 1b
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Guinea pig, Cat, Dog
  • Immunogen

    Synthetic peptide, corresponding to a region within C terminal amino acids 167-216 (YYGINLASAF IILVLMGTWA FLAAGGSCRS LKLCLLCQDK NFLLYNQRSR) of Human Aph 1b according to NP_001139118.

  • Positive control

    • THP-1 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab128335 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 23 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function

    Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
  • Tissue specificity

    Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
  • Sequence similarities

    Belongs to the APH-1 family.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Anterior pharynx defective 1 homolog B (C. elegans) antibody
    • Anterior pharynx defective 1 homolog B antibody
    • Anterior pharynx defective 1B like antibody
    • Anterior pharynx defective 1b short splicing variant antibody
    • APH 1B antibody
    • Aph 1beta antibody
    • APH-1b antibody
    • Aph-1beta antibody
    • Aph1 beta antibody
    • aph1b antibody
    • APH1B_HUMAN antibody
    • Aph1beta antibody
    • DKFZp564D0372 antibody
    • Gamma secretase subunit APH 1B antibody
    • Gamma secretase subunit APH1B antibody
    • Gamma secretase sununit antibody
    • Gamma-secretase subunit Aph-1b antibody
    • Presenilin stabilisation factor like antibody
    • Presenilin-stabilization factor-like antibody
    • PRO 1328 antibody
    • PRO1328 antibody
    • PSFL antibody
    • TAAV 688 antibody
    • TAAV688 antibody
    see all

Images

  • Anti-Aph 1b antibody (ab128335) at 1 µg/ml + THP-1 cell lysate at 10 µg

    Developed using the ECL technique.

    Predicted band size: 23 kDa



    12% gel.

References

This product has been referenced in:

See 1 Publication for this product

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