Key features and details
- Goat polyclonal to APH1a
- Suitable for: ELISA, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-APH1a antibody
See all APH1a primary antibodies
DescriptionGoat polyclonal to APH1a
Tested applicationsSuitable for: ELISA, WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow, Dog
- Human kidney and placenta tissues; Human Brain (Cerebral Cortex) lysate.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityProtein G purified
Our Abpromise guarantee covers the use of ab111992 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.05 - 0.1 µg/ml. Predicted molecular weight: 29 kDa.|
|IHC-P||Use a concentration of 5 µg/ml.|
FunctionEssential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Tissue specificityWidely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
Sequence similaritiesBelongs to the APH-1 family.
Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
- Information by UniProt
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ab111992 at 5 µg/ml staining APH1a in Formalin-Fixed, Paraffin-Embedded Human Kidney tissue by Immunohistochemistry.
ab111992 at 5 µg/ml staining APH1a in Formalin-Fixed, Paraffin-Embedded Human Placenta tissue by Immunohistochemistry.
Anti-APH1a antibody (ab111992) at 0.05 µg/ml + Human Brain (Cerebral Cortex) lysate at 35 µg
Developed using the ECL technique.
Predicted band size: 29 kDa
Primary incubation was 1 hour.
ab111992 has not yet been referenced specifically in any publications.