Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor (ab142400)
- Datasheet
- References (2)
Overview
-
Product name
Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor -
Description
DNA polymerase α, δ and ε inhibitor -
Biological description
DNA polymerase α, δ and ε inhibitor. Tetracyclic diterpene antibiotic. Reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. -
Purity
> 98% -
CAS Number
38966-21-1 -
Chemical structure
Properties
-
Chemical name
(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol -
Molecular weight
338.48 -
Molecular formula
C20H34O4 -
PubChem identifier
457964 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O -
Source
Phoma sp.
-
Research areas
References
This product has been referenced in:
- Zhang TY et al. Positive effects of treatment of donor cells with aphidicolin on the preimplantation development of somatic cell nuclear transfer embryos in Chinese Bama mini-pig (Sus Scrofa). Anim Sci J 83:103-10 (2012). Read more (PubMed: 22339690) »
- Recolin B & Maiorano D Implication of RPA32 phosphorylation in S-phase checkpoint signalling at replication forks stalled with aphidicolin in Xenopus egg extracts. Biochem Biophys Res Commun 427:785-9 (2012). Read more (PubMed: 23047005) »
- Nicodemo D et al. Chromosomal expression and localization of aphidicolin-induced fragile sites in the standard karyotype of river buffalo (Bubalus bubalis). Cytogenet Genome Res 120:178-82 (2008). Read more (PubMed: 18467845) »
