Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor (ab142400)
Key features and details
- DNA polymerase α, δ and ε inhibitor
- CAS Number: 38966-21-1
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Phoma sp.
Overview
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Product name
Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor -
Description
DNA polymerase α, δ and ε inhibitor -
Purity
> 98% -
CAS Number
38966-21-1 -
Chemical structure
Properties
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Chemical name
(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol -
Molecular weight
338.48 -
Molecular formula
C20H34O4 -
PubChem identifier
457964 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O -
Source
Phoma sp.
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Research areas
Images
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Chemical Structure - Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor (ab142400)2D chemical structure image of ab142400, Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (7)
ab142400 has been referenced in 7 publications.
- Wang H et al. Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Oncogene 39:2905-2920 (2020). PubMed: 32029902
- Chen S et al. Nonrandom DNA Segregation Detection under Replication Stress. STAR Protoc 1:100143 (2020). PubMed: 33377037
- Watts LP et al. The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress. Elife 9:N/A (2020). PubMed: 33141022
- Hu X et al. Region-Restrict Astrocytes Exhibit Heterogeneous Susceptibility to Neuronal Reprogramming. Stem Cell Reports 12:290-304 (2019). PubMed: 30713039
- Luo X et al. SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A. J Virol 92:N/A (2018). PubMed: 29643244
- Teng Y et al. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun 9:4115 (2018). PubMed: 30297739
- Xu Y et al. 53BP1 and BRCA1 control pathway choice for stalled replication restart. Elife 6:N/A (2017). PubMed: 29106372