Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor (ab142400)
Overview
-
Product name
Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor -
Description
DNA polymerase α, δ and ε inhibitor -
Biological description
DNA polymerase α, δ and ε inhibitor. Tetracyclic diterpene antibiotic. Reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. -
Purity
> 98% -
CAS Number
38966-21-1 -
Chemical structure
Properties
-
Chemical name
(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol -
Molecular weight
338.48 -
Molecular formula
C20H34O4 -
PubChem identifier
457964 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O -
Source
Phoma sp.
-
Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References
ab142400 has been referenced in 5 publications.
- Wang H et al. Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Oncogene 39:2905-2920 (2020). PubMed: 32029902
- Hu X et al. Region-Restrict Astrocytes Exhibit Heterogeneous Susceptibility to Neuronal Reprogramming. Stem Cell Reports 12:290-304 (2019). PubMed: 30713039
- Luo X et al. SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A. J Virol 92:N/A (2018). PubMed: 29643244
- Teng Y et al. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun 9:4115 (2018). PubMed: 30297739
- Xu Y et al. 53BP1 and BRCA1 control pathway choice for stalled replication restart. Elife 6:N/A (2017). PubMed: 29106372
