Overview

  • Product name

    Apicidin, HDAC inhibitor
  • Description

    Potent HDAC inhibitor
  • Biological description

    Potent histone deacetylase inhibitor (IC50 = 0.7 nM). Inhibits cancer cell proliferation via induction of p21WAF1/Cip1 and gelsolin. Active in vitro and in vivo. Cell-permeable.
  • Purity

    > 95%
  • CAS Number

    183506-66-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Keles E  et al. Apicidin suppresses transcription of 17ß-hydroxysteroid dehydrogenase type 1 in endometrial adenocarcinoma cells. Mol Biol Rep 38:3355-60 (2011). Read more (PubMed: 21086175) »
  • Han JW  et al. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res 60:6068-74 (2000). Read more (PubMed: 11085529) »
  • Darkin-Rattray SJ  et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A 93:13143-7 (1996). Read more (PubMed: 8917558) »

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