Overview

  • Product name

  • Description

    Rabbit polyclonal to APLP2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Chimpanzee
  • Immunogen

    Recombinant fragment, corresponding to a region within N terminal amino acids 17-235 of Human APLP2.

  • Positive control

    • WB: Human HEK-293T, A431, HeLa, HepG2 and A-375 cell lysates; Mouse brain lysate. IHC-P: Mouse liver and fore brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab137597 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 87 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.
  • Tissue specificity

    Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
  • Sequence similarities

    Belongs to the APP family.
    Contains 1 BPTI/Kunitz inhibitor domain.
  • Post-translational
    modifications

    The BPTI/Kunitz inhibitor domain is O-glycosylated.
  • Cellular localization

    Cell membrane. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • amyloid beta (A4) precursor like protein 2 antibody
    • Amyloid like protein 2 antibody
    • Amyloid precursor protein homolog HSD 2 antibody
    • amyloid precursor protein homolog HSD2 antibody
    • Amyloid protein homolog antibody
    • Amyloid-like protein 2 antibody
    • APLP-2 antibody
    • Aplp2 antibody
    • APLP2_HUMAN antibody
    • APPH antibody
    • APPL2 antibody
    • CDEBP antibody
    • CDEI box binding protein antibody
    • CDEI box-binding protein antibody
    see all

Images

  • Paraffin-embedded mouse liver tissue stained for APLP2 using ab137597 at 1/500 dilution in immunohistochemical analysis.

  • Paraffin-embedded mouse fore brain tissue stained for APLP2 using ab137597 at 1/500 dilution in immunohistochemical analysis.

  • All lanes : Anti-APLP2 antibody (ab137597) at 1/1000 dilution

    Lane 1 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
    Lane 2 : A431 (human epidermoid carcinoma cell line) whole cell lysate
    Lane 3 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
    Lane 4 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate
    Lane 5 : A-375 (human malignant melanoma cell line) whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 87 kDa

  • Anti-APLP2 antibody (ab137597) at 1/1000 dilution + Mouse brain lysate at 50 µg

    Predicted band size: 87 kDa

References

ab137597 has not yet been referenced specifically in any publications.

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