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Epigenetics and Nuclear Signaling Chromatin Binding Proteins DNA / RNA binding
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RecombinantRabMAb

Recombinant Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
  • Western blot - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
  • Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR11286(B)] to APOBEC2
  • Suitable for: IHC-P, WB
  • Reacts with: Human

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Overview

  • Product name

    Anti-APOBEC2 antibody [EPR11286(B)]
    See all APOBEC2 primary antibodies
  • Description

    Rabbit monoclonal [EPR11286(B)] to APOBEC2
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IHC-P
    Human
    WB
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide within Human APOBEC2 (Cysteine residue). The exact sequence is proprietary.
    Database link: Q9Y235

  • Positive control

    • Human heart and skeletal muscle tissues; Human fetal muscle and fetal heart lysates.
  • General notes

     

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR11286(B)
  • Isotype

    IgG
  • Research areas

    • Epigenetics and Nuclear Signaling
    • Chromatin Binding Proteins
    • DNA / RNA binding
    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Deamination

Associated products

  • Alternative Versions

    • Anti-APOBEC2 antibody [EPR11286(B)] - BSA and Azide free (ab249542)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab170859 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
ICC
Human
IHC-P
Human
WB
Human
All applications
Mouse
Rat
Application Abreviews Notes
IHC-P
1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB
1/10000 - 1/50000. Predicted molecular weight: 26 kDa.
Notes
IHC-P
1/100 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB
1/10000 - 1/50000. Predicted molecular weight: 26 kDa.
  • Application notes
    Is unsuitable for ICC/IF or IP.
  • Target

    • Relevance

      APOBEC2 belongs to the cytidine and deoxycytidylate deaminase family. It is probable C to U editing enzyme whose physiological substrate is not yet known. It does not display detectable apoB mRNA editing and has a low intrinsic cytidine deaminase activity.
    • Database links

      • Entrez Gene: 10930 Human
      • Entrez Gene: 11811 Mouse
      • Entrez Gene: 301226 Rat
      • Omim: 604797 Human
      • SwissProt: Q9Y235 Human
      • SwissProt: Q9WV35 Mouse
      • Unigene: 555915 Human
      • Unigene: 281793 Mouse
      • Unigene: 163040 Rat
      see all
    • Alternative names

      • APOBEC1-LIKE antibody
      • Apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 antibody
      • Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 2 antibody
      • ARCD1 antibody
      • ARP1 antibody
      • MGC128604 antibody
      • probable C->U-editing enzyme APOBEC-2 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)

      Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human skeletal muscle tissue labeling APOBEC2 with ab170859 at 1/100 dilution.

      Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)

      Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human heart tissue labeling APOBEC2 with ab170859 at 1/100 dilution.

      Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)

      ab170859 showing -ve staining in Human thyroid gland carcinoma tissue.

      Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)

      ab170859 showing -ve staining in Human normal liver tissue.

      Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)

      ab170859 showing -ve staining in Human normal kidney tissue.

      Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)

      ab170859 showing -ve staining in Human cervical carcinoma tissue.

      Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    • Western blot - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
      Western blot - Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
      All lanes : Anti-APOBEC2 antibody [EPR11286(B)] (ab170859) at 1/10000 dilution

      Lane 1 : Human fetal muscle lysate
      Lane 2 : Human fetal heart lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 26 kDa

    • Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)
      Anti-APOBEC2 antibody [EPR11286(B)] (ab170859)

    Protocols

    • Western blot protocols
    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab170859? Please let us know so that we can cite the reference in this datasheet.

    ab170859 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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