• Product name

    Anti-Apolipoprotein CII/ApoC-II antibody
    See all Apolipoprotein CII/ApoC-II primary antibodies
  • Description

    Goat polyclonal to Apolipoprotein CII/ApoC-II
  • Host species

  • Specificity

    Typically less than 1% cross reactivity against other types of apoLipoprotein was detected by ELISA. This antibody reacts with human apoLipoprotein C-II and has negligible cross-reactivity with Type A-I, A-II, B, C-I, C-III, E and J apoLipoproteins.
  • Tested applications

    Suitable for: Dot blot, ELISA, IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length native protein (purified) corresponding to Apolipoprotein CII/ApoC-II.

  • General notes

    This antibody has been used to determine that atherosclerotic lesions in the human aorta contain considerable amounts of lipoproteins. These lipoproteins were observed to be complexed with components of the extracellular matrix (especially LDL and proteoglycans). The role of these matrix-lipoprotein complexes is not entirely clear, however, animal models of atherosclerosis have shown that increased cellular proliferation and increased production of extracellular matrix components occur following injury to the intimal layer of the aorta.

    At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A-1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL). Abcam's apo-lipoproteins are derived from human plasma by density gradient ultracentrifugation and HPLC.

     This product was previously labelled as Apolipoprotein CII




Our Abpromise guarantee covers the use of ab7618 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot 1/5000 - 1/10000.
ELISA 1/4000 - 1/8000.
IHC-P 1/50 - 1/200.
WB Use at an assay dependent dilution.


  • Function

    Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.
  • Tissue specificity

    Liver and intestine.
  • Involvement in disease

    Hyperlipoproteinemia 1B
  • Sequence similarities

    Belongs to the apolipoprotein C2 family.
  • Post-translational

    Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
    Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • APC 2 antibody
    • APC2 antibody
    • Apo CII antibody
    • Apo-CII antibody
    • APOC 2 antibody
    • ApoC II antibody
    • ApoC-II antibody
    • APOC2 antibody
    • APOC2 protein antibody
    • APOC2_HUMAN antibody
    • ApoCII antibody
    • Apolipoprotein C II antibody
    • Apolipoprotein C II precursor antibody
    • Apolipoprotein C2 antibody
    • ApolipoproteinCII antibody
    • MGC75082 antibody
    • ProapoC-II antibody
    • Proapolipoprotein C-II antibody
    see all


ab7618 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A


Thank you for your enquiry and for the detailed protocol. We are very sorry to hear that your customer is having problem with this antibody. We have searched our database and found that this is a popular selling product and your feedback is the first we have received about it not working. Therefore, at this stage, we would suggest that there is either a problem with the vial you received, or modifications to your protocol are needed to obtain a positive result. We would like to make the following comments/suggestions: 1. Fist of all, we would like to emphasize that the antibody should be stored at 4oC only for SHORT TIME as the datasheet suggests (for a couple of days but not more than for a week). According to our order record, Dawinbio ordered this antibody in July and if the product has been kept at 4oC since then (as the reply to this questionnaire says), maybe this is the reason why it does not work properly. 2. We also would like to know what exactly the customer used as positive control. What is the name of the purified and recombinant protein? Is the protein human or from other species? 4. Has the customer also used cell lysate or clinical samples? If yes, we would strongly suggest using protease inhibitors in the lysis buffer to prevent the degradation of the target protein. 5. Is the secondary antibody works properly? Has the customer used it with a different primary antibody? 6. Add 0.1% Tween-20 (which is a mild detergent) to the blocking solution. If the high background signal persists, consider changing the blocking agent. We hope this will help.

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No I'm afraid that we do not have such a protocol - the protocols section of our website features suggested protocols for standard techniques. We are unable to suggest methods for use with specialised equipment.

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