Apoptosis Activator 2 (AAII), Cytochrome c caspase activator and apoptosis inducer (ab141227)

Overview

  • Product name
    Apoptosis Activator 2 (AAII), Cytochrome c caspase activator and apoptosis inducer
  • Description
    Cytochrome c caspase activator and apoptosis inducer
  • Alternative names
    • AAII
  • Biological description
    Cell-permeable cytochrome c caspase activator. Promoting cytochrome-c dependent oligomerization of Apaf-1 into the mature apoptosome. Induces apoptosis in tumor cells (IC50 = ~4 µM).
  • Purity
    > 99%
  • CAS Number
    79183-19-0
  • Chemical structure
    Chemical Structure

Properties

Associated products

References

This product has been referenced in:
  • Farivar TN  et al. Nano - drug Delivery of Apoptosis Activator 2 to AGS Cells by Liposomes Conjugated with Anti-TROP2 Antibody. N Am J Med Sci 4:582-5 (2012). Read more (PubMed: 23181231) »
  • Jayaraman A & Pike CJ Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones. J Neuroendocrinol 21:77-81 (2009). Read more (PubMed: 19094096) »
  • Nguyen JT & Wells JA Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A 100:7533-8 (2003). Read more (PubMed: 12808146) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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