Apoptosis Inducer Kit (Ready-to-use) (ab102480)
Key features and details
- Assay type: Direct
- Sample type: Adherent cells, Suspension cells
Overview
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Product name
Apoptosis Inducer Kit (Ready-to-use) -
Sample type
Adherent cells, Suspension cells -
Assay type
Direct -
Product overview
Apoptosis Inducer Kit (ab102480) contains 5 ready-to-use chemical reagents that induce apoptosis through different mechanisms. Actinomycin D, an antineoplastic antibiotic, inhibits RNA synthesis. Camptothecin, an inhibitor of nuclear topoisomerase, induces apoptosis in many types of cells. Cycloheximide, an active antibiotic against many yeast and fungi, inhibits protein synthesis. Dexamethasone, an active and highly stable glucocorticoid, probably induces apoptosis by binding and activating the intracellular glucocorticoid receptor. Etoposide, a derivative of podophyllotoxin, inhibits topoisomerase activity.
Visit our FAQs page for tips and troubleshooting. -
Notes
This product is manufactured by BioVision, an Abcam company and was previously called K121 Ready-to-use Apoptosis Inducer Set. K121-5 is the same size as the 5 test size of ab102480.
Properties
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Storage instructions
Store at -20°C. Please refer to protocols. -
Components 5 tests Actinomycin D 10mM 1 x 50µl Camptothecin 2mM 1 x 1ml Cycloheximide 100mM 1 x 1ml Dexamethasone 10mM 1 x 1ml Etoposide 100mM 1 x 100µl -
Research areas
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Relevance
Apoptosis Inducers are chemical reagents that induce apoptosis through various mechanisms.
Associated products
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Related Products
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- Z-VAD(OMe)-FMK, Cell permeable, irreversible pan-caspase inhibitor (ab120487)
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- Dorsomorphin (Compound C), AMP-kinase inhibitor (ab120843)
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Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab102480 has been referenced in 5 publications.
- Kim OH et al. Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14. Cell Death Differ 29:1423-1432 (2022). PubMed: 35017647
- Faridnia R et al. Apoptotic blebs from Leishmania major-infected macrophages as a new approach for cutaneous leishmaniasis vaccination. Microb Pathog 147:104406 (2020). PubMed: 32738284
- Rinne P et al. Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation. Arterioscler Thromb Vasc Biol 38:2562-2575 (2018). PubMed: 30354245
- Kim OH et al. Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice. BMB Rep 50:43-48 (2017). Functional Studies . PubMed: 27866511
- Wang H et al. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature 546:426-430 (2017). PubMed: 28607489