Overview

  • Product name

    Apramycin sulfate, protein synthesis inhibitor
  • Description

    Aminoglycoside antibiotic agent. Potent protein synthesis inhibitor.
  • Biological description

    Aminoglycoside antibiotic agent. Potent protein synthesis inhibitor. Inhibits translocation. Shows bactericidal effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    65710-07-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,3R,4S,5S,6S)-2-[[(2R,3S,4R,4aR,6S,7R,8aS)-7-Amino-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy-4-hydroxy-3-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-2-yl]oxy]-5-amino-6-(hydroxymethyl)oxane-3,4-diol sulfuric acid
  • Molecular weight

    637.66
  • Molecular formula

    C21H41N5O11.H2SO4
  • PubChem identifier

    3081544
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CNC1C(C2C(CC(C(O2)OC3C(CC(C(C3O)O)N)N)N)OC1OC4C(C(C(C(O4)CO)N)O)O)O.OS(=O)(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tsai A  et al. The impact of aminoglycosides on the dynamics of translation elongation. Cell Rep 3:497-508 (2013). Read more (PubMed: 23416053) »
  • Balenci D  et al. Structural features of apramycin bound at the bacterial ribosome a site as detected by NMR and CD spectroscopy. Chembiochem 11:166-9 (2010). Read more (PubMed: 20024973) »
  • Perzynski S  et al. Effects of apramycin, a novel aminoglycoside antibiotic on bacterial protein synthesis. Eur J Biochem 99:623-8 (1979). Read more (PubMed: 115690) »

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