Product nameAPS-2-79, KSR-dependent MAPK modulator
DescriptionKSR-dependent MAPK modulator.
- APS 2 79
- APS-2-79 HCl
Kinase suppressor of Ras (KSR)-dependent MAPK modulator (IC50 of KSR2 = 120 ± 23 nM). Modulates signaling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK. Binds to the ATP-binding domain of KSR proteins stabilizing them in an inactive state complexed with MEK.
Storage instructionsShipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
Soluble in DMSO to 228.83mM and in Ethanol to 75.49 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Neilsen BK et al. KSR as a therapeutic target for Ras-dependent cancers. Expert Opin Ther Targets 21:499-509 (2017). Read more (PubMed: 28333549) »
- Dhawan NS et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature 537:112-116 (2016). Read more (PubMed: 27556948) »