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  1. Link

    aqp0-antibody-ab15077.pdf

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Signal Transduction Metabolism Plasma Membrane Channels
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Anti-AQP0 antibody (ab15077)

  • Datasheet
  • SDS
Submit a review Q&A (1)References (9)

Product price, shipping and contact information

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Promotion Information

Abpromise

Guaranteed product quality, expert customer support.

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Key features and details

  • Rabbit polyclonal to AQP0
  • Suitable for: ELISA
  • Reacts with: Human
  • Isotype: IgG

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Overview

  • Product name

    Anti-AQP0 antibody
    See all AQP0 primary antibodies
  • Description

    Rabbit polyclonal to AQP0
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ELISAmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Synthetic peptide corresponding to Human AQP0 (C terminal).

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Constituents: 0.1% BSA, PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Metabolism
    • Plasma Membrane
    • Channels
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cell Adhesion
    • Gap Junctions
    • Neuroscience
    • Sensory System
    • Visual system
    • Metabolism
    • Types of disease
    • Cancer

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab15077 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
Use at an assay dependent concentration.
Notes
ELISA
Use at an assay dependent concentration.

Target

  • Function

    Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.
  • Tissue specificity

    Major component of lens fiber gap junctions.
  • Involvement in disease

    Cataract 15, multiple types
  • Sequence similarities

    Belongs to the MIP/aquaporin (TC 1.A.8) family.
  • Domain

    Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side.
  • Post-translational
    modifications

    Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes.
  • Cellular localization

    Cell membrane. Cell junction > gap junction.
  • Target information above from: UniProt accession P30301 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 280859 Cow
    • Entrez Gene: 4284 Human
    • Entrez Gene: 25480 Rat
    • Omim: 154050 Human
    • SwissProt: P06624 Cow
    • SwissProt: P30301 Human
    • SwissProt: P09011 Rat
    • Unigene: 574026 Human
    • Unigene: 23532 Rat
    see all
  • Alternative names

    • AQP 0 antibody
    • AQP0 antibody
    • Aquaporin antibody
    • Aquaporin 0 antibody
    • Aquaporin-0 antibody
    • Aquaporin0 antibody
    • Lens fiber major intrinsic protein antibody
    • LIM 1 antibody
    • LIM1 antibody
    • Major intrinsic protein 26kD antibody
    • Major intrinsic protein of lens fiber antibody
    • MIP 26 antibody
    • mip antibody
    • MIP_HUMAN antibody
    • MIP26 antibody
    • MP 26 antibody
    • MP26 antibody
    • PALM antibody
    see all

Protocols

  • Western blot protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (9)

Publishing research using ab15077? Please let us know so that we can cite the reference in this datasheet.

ab15077 has been referenced in 9 publications.

  • Li Z  et al. Potent aneugenicity of 1-methylpyrene in human cells dependent on metabolic activation by endogenous enzymes. Arch Toxicol 95:703-713 (2021). PubMed: 33057863
  • Padula SL  et al. Lens fiber cell differentiation occurs independently of fibroblast growth factor receptor signaling in the absence of Pten. Dev Biol 467:1-13 (2020). PubMed: 32858001
  • Yu H  et al. 1-Methylpyrene induces chromosome loss and mitotic apparatus damage in a Chinese hamster V79-derived cell line expressing both human CYP1A2 and sulfotransferase 1A1. Chem Biol Interact 332:109283 (2020). PubMed: 33035519
  • Han L  et al. Triterpenoid Saponins from Anemone flaccida Suppress Tumor Cell Proliferation by Regulating MAPK, PD1/PDL1, and STAT3 Signaling Pathways and Altering Cancer Metabolism. Onco Targets Ther 12:10917-10930 (2019). PubMed: 31849495
  • Raab S  et al. Reprogramming to pluripotency does not require transition through a primitive streak-like state. Sci Rep 7:16543 (2017). PubMed: 29185460
  • Chaffee BR  et al. FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol 410:150-163 (2016). PubMed: 26764128
  • Tan H  et al. Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats. J Neuroinflammation 11:93 (2014). PubMed: 24884762
  • Zhang J  et al. Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor ?B. Neuroscience 261:1-10 (2014). PubMed: 24365462
  • Zhang J  et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology 121:773-85 (2014). PubMed: 25251457

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

Question

AQP0抗体の購入を考えていますが、Positive Controlとなるものはありますか?

Read More

Abcam community

Verified customer

Asked on Nov 06 2007

Answer

いつもお世話になっております。 この度はお問合せいただきましてありがとうございます。 申し訳ありませんが、ab15077のpositive controlを取り扱いしておりません。しかしながら、bovine lens fiberはpositive controlとしてご使用できます。 もしよければ、この抗体や、似ているクローンの文献情報は以下に添付いたします。 Molecular Vision 2003; 9:497-501 [http://www.molvis.org/molvis/v9/a62/] また他にご質問等がございましたら、お気軽にご連絡ください。

Read More

Abcam Scientific Support

Answered on Nov 06 2007

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