Key features and details
- Rabbit polyclonal to AQP0
- Reacts with: Human
- Isotype: IgG
Product nameAnti-AQP0 antibody
See all AQP0 primary antibodies
DescriptionRabbit polyclonal to AQP0
Species reactivityReacts with: Human
Predicted to work with: Rat, Cow
Synthetic peptide corresponding to Human AQP0 (C terminal).
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferConstituents: 0.1% BSA, PBS
Concentration information loading...
PurityImmunogen affinity purified
FunctionWater channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.
Tissue specificityMajor component of lens fiber gap junctions.
Involvement in diseaseCataract 15, multiple types
Sequence similaritiesBelongs to the MIP/aquaporin (TC 1.A.8) family.
DomainAquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side.
modificationsSubject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes.
Cellular localizationCell membrane. Cell junction > gap junction.
- Information by UniProt
- AQP 0 antibody
- AQP0 antibody
- Aquaporin antibody
ab15077 has been referenced in 9 publications.
- Li Z et al. Potent aneugenicity of 1-methylpyrene in human cells dependent on metabolic activation by endogenous enzymes. Arch Toxicol 95:703-713 (2021). PubMed: 33057863
- Padula SL et al. Lens fiber cell differentiation occurs independently of fibroblast growth factor receptor signaling in the absence of Pten. Dev Biol 467:1-13 (2020). PubMed: 32858001
- Yu H et al. 1-Methylpyrene induces chromosome loss and mitotic apparatus damage in a Chinese hamster V79-derived cell line expressing both human CYP1A2 and sulfotransferase 1A1. Chem Biol Interact 332:109283 (2020). PubMed: 33035519
- Han L et al. Triterpenoid Saponins from Anemone flaccida Suppress Tumor Cell Proliferation by Regulating MAPK, PD1/PDL1, and STAT3 Signaling Pathways and Altering Cancer Metabolism. Onco Targets Ther 12:10917-10930 (2019). PubMed: 31849495
- Raab S et al. Reprogramming to pluripotency does not require transition through a primitive streak-like state. Sci Rep 7:16543 (2017). PubMed: 29185460
- Chaffee BR et al. FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol 410:150-163 (2016). PubMed: 26764128
- Tan H et al. Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats. J Neuroinflammation 11:93 (2014). PubMed: 24884762
- Zhang J et al. Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor ?B. Neuroscience 261:1-10 (2014). PubMed: 24365462
- Zhang J et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology 121:773-85 (2014). PubMed: 25251457