Anti-AQP0 antibody (ab15077)

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Overview

  • Product name

    Anti-AQP0 antibody
    See all AQP0 primary antibodies

  • Description

    Rabbit polyclonal to AQP0

  • Host species

    Rabbit

  • Specificity

    ab15077 recognises AQP0.

  • Tested applications

    Suitable for: ELISAmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat, Cow

  • Immunogen

    Synthetic peptide corresponding to Human AQP0 (C terminal).

  • General notes

    Previously labelled as Aquaporin 0. 

Properties

Applications

Our Abpromise guarantee covers the use of ab15077 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 0.5 - 1 µg/ml.

Target

  • Function

    Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

  • Tissue specificity

    Major component of lens fiber gap junctions.

  • Involvement in disease

    Cataract 15, multiple types

  • Sequence similarities

    Belongs to the MIP/aquaporin (TC 1.A.8) family.

  • Domain

    Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side.

  • Post-translational
    modifications

    Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes.

  • Cellular localization

    Cell membrane. Cell junction > gap junction.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • AQP 0 antibody
    • AQP0 antibody
    • Aquaporin antibody
    • Aquaporin 0 antibody
    • Aquaporin-0 antibody
    • Aquaporin0 antibody
    • Lens fiber major intrinsic protein antibody
    • LIM 1 antibody
    • LIM1 antibody
    • Major intrinsic protein 26kD antibody
    • Major intrinsic protein of lens fiber antibody
    • MIP 26 antibody
    • mip antibody
    • MIP_HUMAN antibody
    • MIP26 antibody
    • MP 26 antibody
    • MP26 antibody
    • PALM antibody
    see all

References

This product has been referenced in:

  • Raab S  et al. Reprogramming to pluripotency does not require transition through a primitive streak-like state. Sci Rep 7:16543 (2017). Read more (PubMed: 29185460) »
  • Chaffee BR  et al. FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol 410:150-163 (2016). Read more (PubMed: 26764128) »
See all 5 Publications for this product

Publishing research using ab15077? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

AQP0抗体の購入を考えていますが、Positive Controlとなるものはありますか？

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Answer

いつもお世話になっております。 この度はお問合せいただきましてありがとうございます。 申し訳ありませんが、ab15077のpositive controlを取り扱いしておりません。しかしながら、bovine lens fiberはpositive controlとしてご使用できます。 もしよければ、この抗体や、似ているクローンの文献情報は以下に添付いたします。 Molecular Vision 2003; 9:497-501 [http://www.molvis.org/molvis/v9/a62/] また他にご質問等がございましたら、お気軽にご連絡ください。

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