Overview

  • Product name
  • Description
    Rabbit polyclonal to AQP0
  • Host species
    Rabbit
  • Specificity
    ab15077 recognises AQP0.
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Synthetic peptide corresponding to Human AQP0 (C terminal).

  • General notes

    Previously labelled as Aquaporin 0. 

Properties

Applications

Our Abpromise guarantee covers the use of ab15077 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    ELISA: Use at a concentration of 0.5 - 1 µg/ml.
    WB: Use at a concentration of 1 - 10 µg/ml with ECL detection. Predicted molecular weight: 28 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.
    • Tissue specificity
      Major component of lens fiber gap junctions.
    • Involvement in disease
      Cataract 15, multiple types
    • Sequence similarities
      Belongs to the MIP/aquaporin (TC 1.A.8) family.
    • Domain
      Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side.
    • Post-translational
      modifications
      Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes.
    • Cellular localization
      Cell membrane. Cell junction > gap junction.
    • Information by UniProt
    • Database links
    • Alternative names
      • AQP 0 antibody
      • AQP0 antibody
      • Aquaporin antibody
      • Aquaporin 0 antibody
      • Aquaporin-0 antibody
      • Aquaporin0 antibody
      • Lens fiber major intrinsic protein antibody
      • LIM 1 antibody
      • LIM1 antibody
      • Major intrinsic protein 26kD antibody
      • Major intrinsic protein of lens fiber antibody
      • MIP 26 antibody
      • mip antibody
      • MIP_HUMAN antibody
      • MIP26 antibody
      • MP 26 antibody
      • MP26 antibody
      • PALM antibody
      see all

    References

    This product has been referenced in:
    • Raab S  et al. Reprogramming to pluripotency does not require transition through a primitive streak-like state. Sci Rep 7:16543 (2017). Read more (PubMed: 29185460) »
    • Chaffee BR  et al. FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol 410:150-163 (2016). Read more (PubMed: 26764128) »
    See all 5 Publications for this product

    Customer reviews and Q&As

    Answer

    いつもお世話になっております。 この度はお問合せいただきましてありがとうございます。 申し訳ありませんが、ab15077のpositive controlを取り扱いしておりません。しかしながら、bovine lens fiberはpositive controlとしてご使用できます。 もしよければ、この抗体や、似ているクローンの文献情報は以下に添付いたします。 Molecular Vision 2003; 9:497-501 [http://www.molvis.org/molvis/v9/a62/] また他にご質問等がございましたら、お気軽にご連絡ください。

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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