Anti-AQP0 antibody (ab15077)
Key features and details
- Rabbit polyclonal to AQP0
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-AQP0 antibody
See all AQP0 primary antibodies -
Description
Rabbit polyclonal to AQP0 -
Host species
Rabbit -
Species reactivity
Reacts with: Human
Predicted to work with: Rat, Cow
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Immunogen
Synthetic peptide corresponding to Human AQP0 (C terminal).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Constituents: 0.1% BSA, PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Target
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Function
Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. -
Tissue specificity
Major component of lens fiber gap junctions. -
Involvement in disease
Cataract 15, multiple types -
Sequence similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family. -
Domain
Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side. -
Post-translational
modificationsSubject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes. -
Cellular localization
Cell membrane. Cell junction > gap junction. - Information by UniProt
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Database links
- Entrez Gene: 280859 Cow
- Entrez Gene: 4284 Human
- Entrez Gene: 25480 Rat
- Omim: 154050 Human
- SwissProt: P06624 Cow
- SwissProt: P30301 Human
- SwissProt: P09011 Rat
- Unigene: 574026 Human
see all -
Alternative names
- AQP 0 antibody
- AQP0 antibody
- Aquaporin antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (9)
ab15077 has been referenced in 9 publications.
- Li Z et al. Potent aneugenicity of 1-methylpyrene in human cells dependent on metabolic activation by endogenous enzymes. Arch Toxicol 95:703-713 (2021). PubMed: 33057863
- Padula SL et al. Lens fiber cell differentiation occurs independently of fibroblast growth factor receptor signaling in the absence of Pten. Dev Biol 467:1-13 (2020). PubMed: 32858001
- Yu H et al. 1-Methylpyrene induces chromosome loss and mitotic apparatus damage in a Chinese hamster V79-derived cell line expressing both human CYP1A2 and sulfotransferase 1A1. Chem Biol Interact 332:109283 (2020). PubMed: 33035519
- Han L et al. Triterpenoid Saponins from Anemone flaccida Suppress Tumor Cell Proliferation by Regulating MAPK, PD1/PDL1, and STAT3 Signaling Pathways and Altering Cancer Metabolism. Onco Targets Ther 12:10917-10930 (2019). PubMed: 31849495
- Raab S et al. Reprogramming to pluripotency does not require transition through a primitive streak-like state. Sci Rep 7:16543 (2017). PubMed: 29185460
- Chaffee BR et al. FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol 410:150-163 (2016). PubMed: 26764128
- Tan H et al. Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats. J Neuroinflammation 11:93 (2014). PubMed: 24884762
- Zhang J et al. Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor ?B. Neuroscience 261:1-10 (2014). PubMed: 24365462
- Zhang J et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology 121:773-85 (2014). PubMed: 25251457