Anti-AQP0 antibody (ab176308)

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Key features and details

  • Rabbit polyclonal to AQP0
  • Reacts with: Mouse, Rat, Human
  • Isotype: IgG

Overview

  • Product name

    Anti-AQP0 antibody
    See all AQP0 primary antibodies

  • Description

    Rabbit polyclonal to AQP0

  • Host species

    Rabbit

  • Species reactivity

    Reacts with: Mouse, Rat, Human

  • Immunogen

    Synthetic peptide corresponding to Human AQP0 aa 1-263.
    Database link: P30301

  • Positive control

    • Mouse eyes tissue lysate.

  • General notes

    Previously labelled as Aquaporin 0. 

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Properties

Target

  • Function

    Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

  • Tissue specificity

    Major component of lens fiber gap junctions.

  • Involvement in disease

    Cataract 15, multiple types

  • Sequence similarities

    Belongs to the MIP/aquaporin (TC 1.A.8) family.

  • Domain

    Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side.

  • Post-translational
    modifications

    Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes.

  • Cellular localization

    Cell membrane. Cell junction > gap junction.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • AQP 0 antibody
    • AQP0 antibody
    • Aquaporin antibody
    • Aquaporin 0 antibody
    • Aquaporin-0 antibody
    • Aquaporin0 antibody
    • Lens fiber major intrinsic protein antibody
    • LIM 1 antibody
    • LIM1 antibody
    • Major intrinsic protein 26kD antibody
    • Major intrinsic protein of lens fiber antibody
    • MIP 26 antibody
    • mip antibody
    • MIP_HUMAN antibody
    • MIP26 antibody
    • MP 26 antibody
    • MP26 antibody
    • PALM antibody
    see all

References (0)

Publishing research using ab176308? Please let us know so that we can cite the reference in this datasheet.

ab176308 has not yet been referenced specifically in any publications.

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