Anti-AQP0 antibody (ab176308)
Key features and details
- Rabbit polyclonal to AQP0
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
-
Product name
Anti-AQP0 antibody
See all AQP0 primary antibodies -
Description
Rabbit polyclonal to AQP0 -
Host species
Rabbit -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide corresponding to Human AQP0 aa 1-263.
Database link: P30301 -
Positive control
- Mouse eyes tissue lysate.
-
General notes
Previously labelled as Aquaporin 0.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Target
-
Function
Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. -
Tissue specificity
Major component of lens fiber gap junctions. -
Involvement in disease
Cataract 15, multiple types -
Sequence similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family. -
Domain
Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side. -
Post-translational
modificationsSubject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes. -
Cellular localization
Cell membrane. Cell junction > gap junction. - Information by UniProt
-
Database links
- Entrez Gene: 4284 Human
- Entrez Gene: 17339 Mouse
- Entrez Gene: 25480 Rat
- Omim: 154050 Human
- SwissProt: P30301 Human
- SwissProt: P51180 Mouse
- SwissProt: P09011 Rat
- Unigene: 574026 Human
see all -
Alternative names
- AQP 0 antibody
- AQP0 antibody
- Aquaporin antibody
see all
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab176308 has not yet been referenced specifically in any publications.