Overview

  • Product name

    Anti-AQP11 antibody
  • Description

    Rabbit polyclonal to AQP11
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    antigen sequence: TLVGTSSNPC GVMMQMMLGG MSPETGAVRL LAQ, corresponding to amino acids 92-124 of Human AQP11.

  • Positive control

    • Human kidney tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab122821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

Target

  • Function

    Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
  • Sequence similarities

    Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
  • Domain

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • AQP-11 antibody
    • Aqp11 antibody
    • AQP11_HUMAN antibody
    • Aquaporin-11 antibody

Images

  • Immunofluorescent staining of Human cell line U-2 OS shows positivity in nucleus but not nucleoli and vesicles. Recommended concentration of ab122821 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122821, at 1/20 dilution, staining AQP11 in paraffin-embedded Human kidney tissue by Immunohistochemistry.

References

This product has been referenced in:

  • Guan Y  et al. Effects of dexamethasone on C6 cell proliferation, migration and invasion through the upregulation of AQP1. Oncol Lett 15:7595-7602 (2018). Read more (PubMed: 29740485) »
See 1 Publication for this product

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