• Product name
  • Description
    Rabbit polyclonal to Aquaporin 2
  • Host species
  • Tested applications
    Suitable for: IHC-P, ICC/IF, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Human, Pig
  • Immunogen

    A 15 aa synthetic MAP peptide (Rat) (C terminal). This peptide is predicted to be cytoplasmic.



Our Abpromise guarantee covers the use of ab15116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration. PubMed: 21576461
ICC/IF 1/500.
ELISA 1/10000 - 1/50000.


  • Function
    Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Tissue specificity
    Expressed in renal collecting tubules.
  • Involvement in disease
    Diabetes insipidus, nephrogenic, autosomal
  • Sequence similarities
    Belongs to the MIP/aquaporin (TC 1.A.8) family.
  • Domain
    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
  • Post-translational
    Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.
  • Cellular localization
    Apical cell membrane. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus, trans-Golgi network membrane. Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
  • Information by UniProt
  • Database links
  • Alternative names
    • ADH water channel antibody
    • AQP 2 antibody
    • AQP CD antibody
    • AQP-2 antibody
    • AQP-CD antibody
    • AQP2 antibody
    • AQP2_HUMAN antibody
    • AQPCD antibody
    • Aquaporin 2 collecting duct antibody
    • Aquaporin CD antibody
    • Aquaporin-2 antibody
    • Aquaporin-CD antibody
    • Aquaporin2 antibody
    • Aquaporine 2 antibody
    • Collecting duct water channel protein antibody
    • MGC34501 antibody
    • Water channel aquaporin 2 antibody
    • Water channel protein for renal collecting duct antibody
    • WCH CD antibody
    • WCH-CD antibody
    • WCHCD antibody
    see all


This product has been referenced in:
  • Tao YS  et al. Expression of brain-derived neurotrophic factor in kidneys from normal and cyclosporine-treated rats. BMC Nephrol 19:63 (2018). Read more (PubMed: 29540150) »
  • Whiting JL  et al. AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A 113:E4328-37 (2016). WB . Read more (PubMed: 27402760) »
See all 7 Publications for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Abcam guarantees this product to work in the species/application used in this Abreview.
Immunocytochemistry/ Immunofluorescence
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1µg/mL · Temperature: 25°C
Mouse Cell (mouse kidney TISSUE)
mouse kidney TISSUE
Yes - triton-X

Abcam user community

Verified customer

Submitted Aug 08 2013


Thank you for your enquiry.

I am pleased to help answer your questions and apologize for the delay in responding. I have been waiting for confirmation of some information from our sources.

The Immunogen for ab9566Anti-Aquaporin 1 antibody [1/22] is provided:


This has 9% alignment to mouse Aquaporin 2. I am sorry to confirm that the antibody has not specifically been tested for crossreactivity to aquaporin 2 in the laboratories. However, the alignment to aquaporin 1is very low and we would not expect this antibody to cross react with aquaporin 2

For ab15116 Anti-Aquaporin 2 antibody,the immunogen for this antibody is a peptide comprised of a 15 amino acid sequence from near the C-terminus of aquaporin 2. The 15 amino acid are within the last 50 amino acids of the sequence (NP_037041). Again, I am sorry this antibody has not been specificallytestedfor crossreactivity to aquaporin 1. However, there is again very low alignment to the immunogen to aquaporin 1 so we would not expect it todetect aquaporin 1.

I hope this information will be helpful to you. If you have any further questions, please do not hesitate to contact us.

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