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- Specific References
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Overview
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Product nameAnti-Aquaporin 4 antibody
See all Aquaporin 4 primary antibodies -
DescriptionRabbit polyclonal to Aquaporin 4
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Host speciesRabbit
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Tested applicationsSuitable for: ICC/IF, WBmore details
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Species reactivityReacts with: Mouse, Rat, Human
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Immunogen
Synthetic peptide:
N-CTKGSYMEVEDNRSQVETED
, corresponding to C terminal amino acids 273-291 of Rat Aquaporin 4 (NP_036957.1). -
Positive control
- Rat kidney lysate; Rat kidney tissue
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at -20ºC.
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Storage bufferpH: 7.40
Preservative: 0.09% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
PurityProtein A purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
Applications
Our Abpromise guarantee covers the use of ab125049 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ICC/IF | 1/200 - 1/400. | |
| WB | 1/1000 - 1/4000. Predicted molecular weight: 35 kDa. |
Target
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FunctionForms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
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Tissue specificityBrain - muscle >> heart, kidney, lung, and trachea.
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Sequence similaritiesBelongs to the MIP/aquaporin (TC 1.A.8) family.
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DomainAquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
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Post-translational
modificationsPhosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40%. -
Cellular localizationMembrane.
- Information by UniProt
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Database links
- Entrez Gene: 361 Human
- Entrez Gene: 11829 Mouse
- Entrez Gene: 25293 Rat
- Omim: 600308 Human
- SwissProt: P55087 Human
- SwissProt: P55088 Mouse
- SwissProt: P47863 Rat
- Unigene: 315369 Human
see all -
Alternative names
- AQP 4 antibody
- AQP-4 antibody
- AQP4 antibody
see all
Images
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Western blot - Anti-Aquaporin 4 antibody (ab125049)All lanes : Anti-Aquaporin 4 antibody (ab125049) at 1/2000 dilution
All lanes : Rat kidney lysate
Predicted band size: 35 kDa -
Immunocytochemistry/ Immunofluorescence - Anti-Aquaporin 4 antibody (ab125049)ab125049, at 1/200 dilution, staining Aquaporin 4 in Rat kidney tissue by Immunofluorescence.
References
ab125049 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"