Overview

  • Product name

    AR 231453, GPR119 agonist
  • Description

    Potent, selective GPR119 agonist
  • Biological description

    Potent, selective G-protein coupled receptor 119 (GPR119) agonist (EC50 = 0.68 nM). Enhances glucose-induced insulin release. Antidiabetic activity. Orally active in vivo.
  • Purity

    > 99%
  • CAS Number

    733750-99-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Chu ZL  et al. N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119. Mol Endocrinol 24:161-70 (2010). Read more (PubMed: 19901198) »
  • Semple G  et al. Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem 51:5172-5 (2008). Read more (PubMed: 18698756) »
  • Chu ZL  et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology 148:2601-9 (2007). Read more (PubMed: 17289847) »
See 1 Publication for this product

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