Overview

  • Product name

    AR-A014418, GSK-3 inhibitor
  • Description

    Highly selective GSK-3 inhibitor
  • Biological description

    Highly selective GSK-3 inhibitor (IC50 = 104 nM). ATP competitive (Ki = 38 nM). Selective over cdc2, cdc5 and 26 other kinases. Inhibits tau phosphorylation (ser 396) at a GSK-3 specific site. Blood-brain barrier permeable.
  • Purity

    > 99%
  • CAS Number

    487021-52-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Tunçdemir M  et al. AR-A014418 as a glycogen synthase kinase-3 inhibitor: Anti-apoptotic and therapeutic potential in experimental spinal cord injury. Neurocirugia (Astur) 24:22-32 (2013). Read more (PubMed: 23116585) »
  • Gould TD  et al. AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int J Neuropsychopharmacol 7:387-90 (2004). Read more (PubMed: 15315719) »
  • Bhat R  et al. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem 278:45937-45 (2003). Read more (PubMed: 12928438) »
See all 2 Publications for this product

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