- References (2)
Product nameAR-A014418, GSK-3 inhibitor
DescriptionHighly selective GSK-3 inhibitor
Biological descriptionHighly selective GSK-3 inhibitor (IC50 = 104 nM). ATP competitive (Ki = 38 nM). Selective over cdc2, cdc5 and 26 other kinases. Inhibits tau phosphorylation (ser 396) at a GSK-3 specific site. Blood-brain barrier permeable.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- PI3K/Akt signaling
- Glycogen synthase kinase
This product has been referenced in:
- Tunçdemir M et al. AR-A014418 as a glycogen synthase kinase-3 inhibitor: Anti-apoptotic and therapeutic potential in experimental spinal cord injury. Neurocirugia (Astur) 24:22-32 (2013). Read more (PubMed: 23116585) »
- Gould TD et al. AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int J Neuropsychopharmacol 7:387-90 (2004). Read more (PubMed: 15315719) »
- Bhat R et al. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem 278:45937-45 (2003). Read more (PubMed: 12928438) »