Overview

  • Product name

    Anti-ARA9 antibody [EPR13585]
    See all ARA9 primary antibodies
  • Description

    Rabbit monoclonal [EPR13585] to ARA9
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human ARA9 aa 1-100. The exact sequence is proprietary.
    Database link: O00170

  • Positive control

    • HeLa, Jurkat, HepG2, C6, Raw264.7 and NIH/3T3 cell lysates; Human thymus, Mouse brain, Mouse heart, Mouse kidney, Mouse spleen, Rat heart and Rat kidney lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.01% Sodium azide
    Constituents: 59% PBS, 40% Glycerol, 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Monoclonal
  • Clone number

    EPR13585
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab192024 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa).

Target

  • Function

    May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
    Cellular negative regulator of the hepatitis B virus (HBV) X protein.
  • Tissue specificity

    Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.
  • Involvement in disease

    Defects in AIP are a cause of familial isolated pituitary adenoma (FIPA) [MIM:102200].
    Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA) [MIM:102200]; also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma.
    Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA) [MIM:219090]; also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
    Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]; also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma.
  • Sequence similarities

    Contains 1 PPIase FKBP-type domain.
    Contains 2 TPR repeats.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • AH receptor interacting protein antibody
    • AH receptor-interacting protein antibody
    • AIP antibody
    • AIP_HUMAN antibody
    • ARA 9 antibody
    • ARA9 antibody
    • Aryl hydrocarbon receptor interacting protein antibody
    • Aryl-hydrocarbon receptor-interacting protein antibody
    • fa03h10 antibody
    • FKBP 16 antibody
    • FKBP 37 antibody
    • FKBP16 antibody
    • FKBP37 antibody
    • HBV X associated protein 2 antibody
    • HBV X associated protein antibody
    • HBV X-associated protein 2 antibody
    • HBVX associated protein antibody
    • Immunophilin homolog ARA 9 antibody
    • Immunophilin homolog ARA9 antibody
    • SMTPHN antibody
    • XAP 2 antibody
    • XAP-2 antibody
    • XAP2 antibody
    see all

Images

  • All lanes : Anti-ARA9 antibody [EPR13585] (ab192024) at 1/10000 dilution

    Lane 1 : HeLa cell lysate
    Lane 2 : Jurkat cell lysate
    Lane 3 : HepG2 cell lysate
    Lane 4 : Human thymus cell lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size: 38 kDa
    Observed band size: 38 kDa



    Blocking/dilution buffer: 5% NFDM/TBST.

  • All lanes : Anti-ARA9 antibody [EPR13585] (ab192024) at 1/1000 dilution

    Lane 1 : Mouse brain lysate
    Lane 2 : Mouse heart lysate
    Lane 3 : Mouse kidney lysate
    Lane 4 : Mouse spleen lysate
    Lane 5 : Rat heart lysate
    Lane 6 : Rat kidney lysate
    Lane 7 : C6 cell lysate
    Lane 8 : Raw 264.7 cell lysate
    Lane 9 : NIH/3T3 cell lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size: 38 kDa
    Observed band size: 38 kDa



    Blocking/dilution buffer: 5% NFDM /TBST.

References

This product has been referenced in:

  • Cai F  et al. A Novel Mutation of Aryl Hydrocarbon Receptor Interacting Protein Gene Associated with Familial Isolated Pituitary Adenoma Mediates Tumor Invasion and Growth Hormone Hypersecretion. World Neurosurg N/A:N/A (2018). Read more (PubMed: 30447469) »
See 1 Publication for this product

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