Arabinofuranosylguanine (ara-G), DNA synthesis inhibitor (ab146649)

Overview

  • Product name

    Arabinofuranosylguanine (ara-G), DNA synthesis inhibitor
  • Description

    DNA synthesis inhibitor; Apoptosis inducer; Antimetabolite and antineoplastic
  • Alternative names

    • 9-beta-D-arabinofuranosylguanine
    • Nine-beta-D-arabinofuranosylguanine
  • Biological description

    Nucleoside analog. Converted by cellular kinases to the active 5'-triphosphate (Ara-GTP) and subsequently incorporated into DNA leading to inhibition of DNA synthesis and apoptosis.

  • Purity

    > 99%
  • CAS Number

    38819-10-2
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    283.24
  • Molecular formula

    C10H13N5O5
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Yamauchi T  et al. Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line. BMC Cancer 14:547 (2014). Read more (PubMed: 25070259) »
  • Fyrberg A  et al. Induction of fetal hemoglobin and ABCB1 gene expression in 9-ß-D-arabinofuranosylguanine-resistant MOLT-4 cells. Cancer Chemother Pharmacol 68:583-91 (2011). Read more (PubMed: 21110023) »
  • Curbo S  et al. Effects of 9-beta-D-arabinofuranosylguanine on mitochondria in CEM T-lymphoblast leukemia cells. Biochem Biophys Res Commun 307:942-7 (2003). Read more (PubMed: 12878202) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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