Product nameArabinofuranosylguanine (ara-G), DNA synthesis inhibitor
DescriptionDNA synthesis inhibitor; Apoptosis inducer; Antimetabolite and antineoplastic
Nucleoside analog. Converted by cellular kinases to the active 5'-triphosphate (Ara-GTP) and subsequently incorporated into DNA leading to inhibition of DNA synthesis and apoptosis.
Storage instructionsStore at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Yamauchi T et al. Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line. BMC Cancer 14:547 (2014). Read more (PubMed: 25070259) »
- Fyrberg A et al. Induction of fetal hemoglobin and ABCB1 gene expression in 9-ß-D-arabinofuranosylguanine-resistant MOLT-4 cells. Cancer Chemother Pharmacol 68:583-91 (2011). Read more (PubMed: 21110023) »
- Curbo S et al. Effects of 9-beta-D-arabinofuranosylguanine on mitochondria in CEM T-lymphoblast leukemia cells. Biochem Biophys Res Commun 307:942-7 (2003). Read more (PubMed: 12878202) »