Product nameArbidol hydrochloride, Indole-based antiviral and anti-inflammatory agent
DescriptionBroad-spectrum indole-based antiviral and anti-inflammatory used for influenza infection treatment
- 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic acid, ethyl ester, monohydrochloride
- Arbidol HCl
- ethyl-6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-indole-3-carboxylate hydrochloride monohydrate
Broad-spectrum indole-based antiviral that has demonstrated activity against a number of enveloped and non-enveloped viruses. Used clinically to treat influenza. Inhibits fusion between the viral capsid and the cell membrane of the target cell, thus preventing viral infection. Displays anti-inflammatory activity.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Liu Q et al. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin 34:1075-83 (2013). Read more (PubMed: 23770981) »
- Villalaín J Membranotropic effects of arbidol, a broad anti-viral molecule, on phospholipid model membranes. J Phys Chem B 114:8544-54 (2010). Read more (PubMed: 20527735) »
- Boriskin YS et al. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem 15:997-1005 (2008). Read more (PubMed: 18393857) »
- Shi L et al. Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo. Arch Virol 152:1447-55 (2007). Read more (PubMed: 17497238) »