Overview

  • Product name

    Anti-Arg2 antibody [EPR9472]
    See all Arg2 primary antibodies
  • Description

    Rabbit monoclonal [EPR9472] to Arg2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, Flow Cytmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Arg2 aa 1-100 (N terminal). The exact sequence is proprietary.

  • Positive control

    • 293T, Jurkat and Caco 2 cell lysates; permeabilized 293T cells.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab139183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 39 kDa.
Flow Cyt 1/100 - 1/500.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Function

      May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
    • Tissue specificity

      Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas.
    • Pathway

      Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
    • Sequence similarities

      Belongs to the arginase family.
    • Cellular localization

      Mitochondrion.
    • Information by UniProt
    • Database links

    • Alternative names

      • ARG2 antibody
      • ARGI2_HUMAN antibody
      • Arginase II mitochondrial antibody
      • Arginase type II antibody
      • Arginase-2 antibody
      • arginase-2, mitochondrial antibody
      • Kidney arginase antibody
      • Kidney type arginase antibody
      • Kidney-type arginase antibody
      • L arginine amidinohydrolase antibody
      • L arginine ureahydrolase antibody
      • mitochondrial antibody
      • Non hepatic arginase antibody
      • Non-hepatic arginase antibody
      • Nonhepatic arginase antibody
      • Type II arginase antibody
      see all

    Images

    • All lanes : Anti-Arg2 antibody [EPR9472] (ab139183) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : Jurkat cell lysate
      Lane 3 : Caco 2 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 39 kDa

    • Flow cytometric analysis of permeabilized 293T cells labelling Arg2 with ab139183 at 1/100 dilution (red) or a rabbit IgG (negative) (green).

    References

    ab139183 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab139183.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

    Sign up