Overview

  • Product name

    Anti-Arg2 antibody - N-terminal
    See all Arg2 primary antibodies
  • Description

    Rabbit polyclonal to Arg2 - N-terminal
  • Host species

    Rabbit
  • Specificity

    No cross reactivity with other proteins.
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Rat, Human
    Predicted to work with: Mouse, Rabbit, Cow
  • Immunogen

    Synthetic peptide corresponding to Human Arg2 aa 67-85 (N terminal).
    Sequence:

    DFGDLSFTPVPKDDLYNNL


    Database link: P78540

  • Positive control

    • Rat lung, rat testis, A549 and 293T cell lysates; Human mammary cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab191029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 39 kDa.

Target

  • Function

    May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
  • Tissue specificity

    Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas.
  • Pathway

    Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
  • Sequence similarities

    Belongs to the arginase family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • ARG2 antibody
    • ARGI2_HUMAN antibody
    • Arginase II mitochondrial antibody
    • Arginase type II antibody
    • Arginase-2 antibody
    • arginase-2, mitochondrial antibody
    • Kidney arginase antibody
    • Kidney type arginase antibody
    • Kidney-type arginase antibody
    • L arginine amidinohydrolase antibody
    • L arginine ureahydrolase antibody
    • mitochondrial antibody
    • Non hepatic arginase antibody
    • Non-hepatic arginase antibody
    • Nonhepatic arginase antibody
    • Type II arginase antibody
    see all

Images

  • Immunohistochemical analysis of Paraffin-embedded Human mammary cancer tissue labeling Arg2 with ab191029 at 1 µg/ml.

  • All lanes : Anti-Arg2 antibody - N-terminal (ab191029) at 0.5 µg/ml

    Lane 1 : Rat lung tissue lysate
    Lane 2 : Rat testis tissue lysate
    Lane 3 : A549 cell lysate
    Lane 4 : 293T cell lysate

    Predicted band size: 39 kDa

References

ab191029 has not yet been referenced specifically in any publications.

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