Overview

  • Product name

    Argatroban monohydrate, Thrombin inhibitor
  • Description

    Potent competitive thrombin inhibitor
  • Biological description

    Potent competitive thrombin inhibitor (Ki = 19 nM). Anticoagulant activity. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    141396-28-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid monohydrate
  • Molecular weight

    526.65
  • Molecular formula

    C23H36N6O5S.H2O
  • PubChem identifier

    92721
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CCN(C(C1)C(=O)O)C(=O)C(CCCN=C(N)N)NS(=O)(=O)C2=CC=CC3=C2NCC(C3)C.O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jang IK  et al. Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 81:219-25 (1990). Read more (PubMed: 2297828) »
  • Fitzgerald DJ & Fitzgerald GA Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc Natl Acad Sci U S A 86:7585-9 (1989). Read more (PubMed: 2508092) »
  • Kikumoto R  et al. Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 23:85-90 (1984). Read more (PubMed: 6691968) »

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