Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab122350 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionFunctions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
Tissue specificityWidely expressed with higher expression in brain, heart, skeletal muscle and placenta.
Sequence similaritiesContains 1 PDZ (DHR) domain.
Contains 1 PH domain.
Contains 1 Rho-GAP domain.
Cellular localizationGolgi apparatus membrane. Cell junction. Cytoplasmic vesicle membrane. Cytoplasm > cytoskeleton. Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
- Information by UniProt
- Arhgap21 antibody
- KIAA1424 antibody
- RHG21_HUMAN antibody
ab122350 has not yet been referenced specifically in any publications.