Overview

  • Product name
  • Description
    Mouse polyclonal to ARHGEF10
  • Host species
    Mouse
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to amino acids 207-570 of Human ARHGEF10 Isoform 3 (AAH40474.1)

  • Positive control
    • ARHGEF10-transfected 293T cell lysate. HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab168936 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 152 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • Function
    May play a role in developmental myelination of peripheral nerves.
  • Involvement in disease
    Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.
  • Sequence similarities
    Contains 1 DH (DBL-homology) domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • ARHGA_HUMAN antibody
    • ARHGEF10 antibody
    • DKFZp686H0726 antibody
    • GEF10 antibody
    • KIAA0294 antibody
    • MGC131664 antibody
    • Rho guanine nucleotide exchange factor (GEF) 10 antibody
    • Rho guanine nucleotide exchange factor 10 antibody
    see all

Images

  • All lanes : Anti-ARHGEF10 antibody (ab168936) at 1 µg/ml

    Lane 1 : ARHGEF10-transfected 293T cell lysate (41.8 KDa)
    Lane 2 : non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Developed using the ECL technique.

    Predicted band size: 152 kDa

  • Immunofluorescent analysis of HeLa cells, labeling ARHGEF10 with ab168936 at 10 µg/ml.

References

ab168936 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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