Overview

  • Product name

  • Description

    Rabbit polyclonal to ARHGEF14
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 54-307 of Human ARHGEF14 (NP_001106203).

  • Positive control

    • Molt-4 and Raji whole cell lysates; 293T, A431, H1299, HeLa and HepG2 whole cell lysate (ab7900)

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab96395 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 128 kDa.

Target

  • Function

    Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.
  • Sequence similarities

    Belongs to the MCF2 family.
    Contains 1 CRAL-TRIO domain.
    Contains 1 DH (DBL-homology) domain.
    Contains 1 PH domain.
    Contains 1 SH3 domain.
    Contains 1 spectrin repeat.
  • Domain

    The CRAL-TRIO domain is involved in interaction with inositol phospholipids.
    The DH domain is involved in interaction with CCPG1.
  • Cellular localization

    Cytoplasm. Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ARHGEF 14 antibody
    • DBL''s big sister antibody
    • DBS antibody
    • FLJ12122 antibody
    • Guanine nucleotide exchange factor DBS antibody
    • KIAA0362 antibody
    • MCF 2L antibody
    • MCF.2 cell line derived transforming sequence like antibody
    • MCF.2 transforming sequence-like antibody
    • MCF2 like protein antibody
    • MCF2 transforming sequence like protein antibody
    • MCF2-transforming sequence-like protein antibody
    • Mcf2l antibody
    • MCF2L_HUMAN antibody
    • OST antibody
    • OST oncogene antibody
    see all

Images

  • All lanes : Anti-ARHGEF14 antibody (ab96395) at 1/1000 dilution

    Lane 1 : Molt-4 whole cell lysate
    Lane 2 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 128 kDa



    5% SDS PAGE

References

ab96395 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab96395.
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