Anti-ARHGEF3 antibody (ab136064)
Key features and details
- Rabbit polyclonal to ARHGEF3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ARHGEF3 antibody
See all ARHGEF3 primary antibodies -
Description
Rabbit polyclonal to ARHGEF3 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide derived from the C terminal region of Human ARHGEF3.
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Positive control
- HeLa cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab136064 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 60 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 60 kDa. |
Target
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Relevance
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. ARHGEF3 encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in ARHGEF3 plays a role in the determination of bone mineral density (BMD), suggesting a role in postmenopausal osteoporosis. -
Cellular localization
Cytoplasmic -
Database links
- Entrez Gene: 50650 Human
- Entrez Gene: 71704 Mouse
- Entrez Gene: 290541 Rat
- Omim: 612115 Human
- SwissProt: Q9NR81 Human
- SwissProt: Q91X46 Mouse
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Alternative names
- 1200004I24Rik antibody
- 59.8 kDA protein antibody
- 9830169H03Rik antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab136064 has been referenced in 1 publication.
- Park J et al. Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E). Blood 130:1430-1440 (2017). PubMed: 28694326