Overview

  • Product name

  • Description

    Rabbit polyclonal to ARHGEF3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C terminal region of Human ARHGEF3.

  • Positive control

    • HeLa cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab136064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 60 kDa.

Target

  • Relevance

    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. ARHGEF3 encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in ARHGEF3 plays a role in the determination of bone mineral density (BMD), suggesting a role in postmenopausal osteoporosis.
  • Cellular localization

    Cytoplasmic
  • Database links

  • Alternative names

    • 1200004I24Rik antibody
    • 59.8 kDA protein antibody
    • 9830169H03Rik antibody
    • ARHGEF 3 antibody
    • C76747 antibody
    • DKFZP434F2429 antibody
    • Exchange factor found in platelets and leukemic and neuronal tissues antibody
    • Exchange factor found in platelets and leukemic and neuronal tissues XPLN antibody
    • FLJ98126 antibody
    • GEF 3 antibody
    • GEF3 antibody
    • MGC118905 antibody
    • Rho guanine nucleotide exchange factor (GEF) 3 antibody
    • Rho guanine nucleotide exchange factor 3 antibody
    • RhoGEF protein antibody
    • STA 3 antibody
    • STA3 antibody
    • XPLN antibody
    see all

Images

  • Anti-ARHGEF3 antibody (ab136064) at 1/500 dilution + HeLa cell lysate at 30 µg

    Predicted band size: 60 kDa

References

This product has been referenced in:

  • Park J  et al. Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E). Blood 130:1430-1440 (2017). Read more (PubMed: 28694326) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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