Key features and details
- Rabbit polyclonal to Aromatase - C-terminal
- Suitable for: IHC-P, WB
- Reacts with: Rat
- Isotype: IgG
Product nameAnti-Aromatase antibody - C-terminal
See all Aromatase primary antibodies
DescriptionRabbit polyclonal to Aromatase - C-terminal
SpecificityNo cross reactivity with other proteins.
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Rat
- Rat brain, thymus and kidney tissue lysates; Rat brain tissue.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate
Concentration information loading...
PurityImmunogen affinity purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Our Abpromise guarantee covers the use of ab191093 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
|WB||Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 58 kDa.|
FunctionCatalyzes the formation of aromatic C18 estrogens from C19 androgens.
Tissue specificityBrain, placenta and gonads.
Involvement in diseaseDefects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity.
Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:107910]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.
Sequence similaritiesBelongs to the cytochrome P450 family.
- Information by UniProt
- ARO antibody
- ARO1 antibody
- Aromatase antibody
All lanes : Anti-Aromatase antibody - C-terminal (ab191093) at 0.5 µg/ml
Lane 1 : Rat brain tissue lysates
Lane 2 : Rat thymus tissue lysates
Lane 3 : Rat kidney tissue lysates
Predicted band size: 58 kDa
The detection limit for ab191093 is approximately 5 ng/lane under reducing conditions.
Immunohistochemical analysis of paraffin-embedded Rat brain tissue labeling Aromatase with ab191093 at 1 µg/ml.
ab191093 has not yet been referenced specifically in any publications.