Overview

  • Product name

    Anti-ARPP-19 (phospho S109) antibody - C-terminal
    See all ARPP-19 primary antibodies
  • Description

    Rabbit polyclonal to ARPP-19 (phospho S109) - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Xenopus tropicalis
  • Immunogen

    Synthetic peptide corresponding to Xenopus tropicalis ARPP-19 (C terminal) (phospho S109).
    Database link: Q28GU6

  • General notes

    Previously labelled as ARP19.

Properties

Applications

Our Abpromise guarantee covers the use of ab196340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000. Predicted molecular weight: 13 kDa.

Target

  • Function

    Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
  • Sequence similarities

    Belongs to the endosulfine family.
  • Post-translational
    modifications

    Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.
    Isoform ARPP-16 contains a N-acetylmethionine at position 1.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

    • Alternative names

      • ARP19 antibody
      • ARP19_HUMAN antibody
      • ARPP-19 antibody
      • Arpp19 antibody
      • cAMP-regulated phosphoprotein 19 antibody
      see all

    References

    ab196340 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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