Overview

  • Product name

    Anti-ARS2 antibody - C-terminal
    See all ARS2 primary antibodies
  • Description

    Goat polyclonal to ARS2 - C-terminal
  • Host species

    Goat
  • Specificity

    ab206316 is expected to recognize all reported isoform (NP_056992.4; NP_001122324.1; NP_001122325.1; NP_001122326.1).
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Hamster, Cow
  • Immunogen

    Synthetic peptide corresponding to Human ARS2 aa 857-871 (C terminal) (Cysteine residue).
    Sequence:

    DPRAIVEYRDLDAPD


    Database link: Q9BXP5

  • Positive control

    • Daudi cell lysate; mouse spleen lysate, Rat testis lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab206316 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 140 kDa (predicted molecular weight: 100 kDa).
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
  • Tissue specificity

    Ubiquitously expressed.
  • Sequence similarities

    Belongs to the ARS2 family.
  • Cellular localization

    Nucleus > nucleoplasm. Cytoplasm. Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way.
  • Information by UniProt
  • Database links

  • Alternative names

    • ARS2 protein antibody
    • Arsenate resistance protein ARS2 antibody
    • Arsenite resistance protein 2 antibody
    • Arsenite resistance protein antibody
    • Arsenite-resistance protein 2 antibody
    • ASR2 antibody
    • MGC126427 antibody
    • Serrate antibody
    • Serrate RNA effector molecule antibody
    • Serrate RNA effector molecule homolog (Arabidopsis) antibody
    • Serrate RNA effector molecule homolog antibody
    • SRRT antibody
    • SRRT_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of paraffin embedded Human uterus tissue, staining ARS2 with ab206316 at 5µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • All lanes : Anti-ARS2 antibody - C-terminal (ab206316) at 0.1 µg/ml

    Lane 1 : Daudi cell lysate in RIPA buffer
    Lane 2 : mouse spleen lysate in RIPA buffer

    Lysates/proteins at 35 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 100 kDa
    Observed band size: 140 kDa
    why is the actual band size different from the predicted?



    The observed molecular weight is explained by the acetylation of the protein and it corresponds to earlier findings with different antibodies from other commercial sources.

  • Anti-ARS2 antibody - C-terminal (ab206316) at 0.1 µg/ml + Rat testis tissue lysate at 35 µg

    Predicted band size: 100 kDa



    The observed molecular weight is explained by the acetylation of the protein and it corresponds to earlier findings with different antibodies from other commercial sources.

References

ab206316 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab206316.
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