• Product name

    Anti-ARSA/ASA antibody [EPR11039]
    See all ARSA/ASA primary antibodies
  • Description

    Rabbit monoclonal [EPR11039] to ARSA/ASA
  • Host species

  • Tested applications

    Suitable for: IHC-P, WBmore details
    Unsuitable for: Flow Cyt,ICC or IP
  • Species reactivity

    Reacts with: Mouse, Human
    Does not react with: Rat
  • Immunogen

    within Human ARSA/ASA aa 450 to the C-terminus. The exact sequence is proprietary.
    Database link: P15289

  • Positive control

    • Human skin, A431 and HeLa lysates; Human colon and kidney tissues.
  • General notes

    Previously labelled as ARSA.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab174844 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB 1/1000 - 1/5000. Detects a band of approximately 60-62 kDa (predicted molecular weight: 54 kDa).
  • Application notes
    Is unsuitable for Flow Cyt,ICC or IP.
  • Target

    • Function

      Hydrolyzes cerebroside sulfate.
    • Involvement in disease

      Defects in ARSA are a cause of leukodystrophy metachromatic (MLD) [MIM:250100]. MLD is a disease due to a lysosomal storage defect. It is characterized by intralysosomal storage of cerebroside-3-sulfate in neural and non-neural tissues, with a diffuse loss of myelin in the central nervous system. Progressive demyelination causes a variety of neurological symptoms, including gait disturbances, ataxias, optical atrophy, dementia, seizures, and spastic tetraparesis. Three forms of the disease can be distinguished according to the age at onset: late-infantile, juvenile and adult.
      Arylsulfatase A activity is defective in multiple sulfatase deficiency (MSD) [MIM:272200]. MSD is a disorder characterized by decreased activity of all known sulfatases. MSD is due to defects in SUMF1 resulting in the lack of post-translational modification of a highly conserved cysteine into 3-oxoalanine. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.
    • Sequence similarities

      Belongs to the sulfatase family.
    • Post-translational

      The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD).
    • Cellular localization

    • Information by UniProt
    • Database links

    • Alternative names

      • arsA antibody
      • ARSA_HUMAN antibody
      • arylsulfatase A antibody
      • Arylsulfatase A component C antibody
      • As 2 antibody
      • AS A antibody
      • As2 antibody
      • ASA antibody
      • AW212749 antibody
      • C230037L18Rik antibody
      • Cerebroside-sulfatase antibody
      • metachromatic leucodystrophy antibody
      • MGC125207 antibody
      • MLD antibody
      • OTTHUMP00000196546 antibody
      • OTTHUMP00000196548 antibody
      • TISP73 antibody
      see all


    • All lanes : Anti-ARSA/ASA antibody [EPR11039] (ab174844) at 1/1000 dilution

      Lane 1 : Human skin lysates
      Lane 2 : A431 cell lysates
      Lane 3 : HeLa cell lysates

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 54 kDa

    • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon tissue labeling ARSA/ASA with ab174844 at 1/50 dilution.

    • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling ARSA/ASA with ab174844 at 1/50 dilution.


    ab174844 has not yet been referenced specifically in any publications.

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