Artemisinin, Antimalarial compound (ab141308)
- Datasheet
- References
Overview
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Product nameArtemisinin, Antimalarial compound
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DescriptionAntimalarial compound
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Alternative names
- Qinghaosu
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Biological descriptionAntimalarial compound. Forms highly alkylating free radicals and reactive oxygen species (ROS°) on interaction with iron. Additionally shows anticancer and antitumor properties. Active in vivo.
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Purity> 99%
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CAS Number63968-64-9
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Chemical structure
Properties
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Chemical name(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
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Molecular weight282.34
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Molecular formulaC15H22O5
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PubChem identifier68827
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Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 50 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILESO=C1O[C@@H]4O[C@@]2(C)CC[C@H]3[C@H](C)CC[C@@H]([C@H]1C)[C@]34OO2
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Source
Artemisia annua
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Research areas
- Biochemicals
- Research Area
- Alzheimer's Disease
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Apoptosis & cell cycle
- Growth factors
- PDGFR
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Apoptosis & cell cycle
- Growth factors
- VEGFR
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Obesity
- Signaling
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Pain & inflammation
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
- Biochemicals
- Research Area
- Respiratory disease
- Apoptosis & cell cycle
- Cyclin-dependent kinase
- Inhibitors
References
This product has been referenced in:
- Crespo-Ortiz MP & Wei MQ Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. J Biomed Biotechnol 2012:247597 (2012). Read more (PubMed: 22174561) »
- Balint GA Artemisinin and its derivatives: an important new class of antimalarial agents. Pharmacol Ther 90:261-5 (0). Read more (PubMed: 11578659) »
- Singh NP & Lai HC Artemisinin induces apoptosis in human cancer cells. Anticancer Res 24:2277-80 (0). Read more (PubMed: 15330172) »
